Cutaneous graft-versus-host reaction lacks evidence of cutaneous cytomegalovirus by the immunoperoxidase technique

Thomas D. Horn, Evan R. Farmer, Georgia Boyce Vogelsang, John R. Wingard, George W. Santos

Research output: Contribution to journalArticle

Abstract

Sixty skin biopsy specimens from 21 bone-marrow transplant patients were evaluated for the presence of cytomegalovirus (CMV) using two monoclonal antibodies to early and late antigens. Each patient had at least one biopsy showing an acute graft-versus-host reaction (GVHR), grade 2, and one positive culture for CMV from blood, bone marrow or urine. In no case could CMV antigens be identified in biopsies showing an acute or chronic cutaneous GVHR or in any other of the skin biopsies obtained from these patients. While CMV may play a role in immunologic events culminating in graft-versus-host disease (GVHD), this immunoperoxidase study did not reveal evidence of viral antigens in tissue displaying features of cutaneous GVHR.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalJournal of Investigative Dermatology
Volume93
Issue number1
StatePublished - Jul 1989

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Graft vs. host reactions
Biopsy
Cytomegalovirus
Immunoenzyme Techniques
Transplants
Skin
Bone
Bone Marrow
Antigens
Viral Antigens
Graft vs Host Disease
Grafts
Blood
Monoclonal Antibodies
Urine
Tissue

ASJC Scopus subject areas

  • Dermatology

Cite this

Cutaneous graft-versus-host reaction lacks evidence of cutaneous cytomegalovirus by the immunoperoxidase technique. / Horn, Thomas D.; Farmer, Evan R.; Vogelsang, Georgia Boyce; Wingard, John R.; Santos, George W.

In: Journal of Investigative Dermatology, Vol. 93, No. 1, 07.1989, p. 92-95.

Research output: Contribution to journalArticle

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