Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade: Clinicopathologic Analysis of the Nonlichenoid Histologic Pattern

Genevieve J. Kaunitz, Manisha Loss, Hira Rizvi, Sowmya Ravi, Jonathan D. Cuda, Karen Bleich, Jessica Esandrio, Inbal Sander, Dung Le, Luis A. Diaz, Julie Brahmer, Charles G. Drake, Travis J. Hollmann, Mario E. Lacouture, Matthew D. Hellmann, Evan Lipson, Janis M Taube

Research output: Contribution to journalArticle

Abstract

Cutaneous eruptions are among the most common immune-related adverse events (irAEs) associated with anti-programmed cell death protein 1/programmed cell death ligand 1 therapy, and are often clinically and histologically characterized as lichenoid. Nonlichenoid patterns may also occur and are likely to be encountered by surgical pathologists, given the increasing clinical use of these agents. The purpose of this study is to describe the histopathologic features of nonlichenoid cutaneous irAEs from patients receiving anti-programmed cell death protein 1/programmed cell death ligand 1 therapies for a variety of underlying advanced malignancies. Sixteen patients with 17 biopsied eruptions were included from 2 academic institutions with extensive experience administering and monitoring responses to immune checkpoint blockade as well as treating the potential side effects. Eruptions occurred a median of 10 days (range, 1 d to 11.4 mo) after treatment initiation. Nearly half of specimens demonstrated either a psoriasiform/spongiotic or an urticarial-type reaction pattern on histologic review. Patterns consistent with Grover disease, bullous pemphigoid, and granulomatous dermatitis were also observed. Nearly two-thirds of patients required systemic corticosteroids for treatment of the cutaneous irAE, and 19% of patients discontinued immunotherapy due to their skin eruptions. 75% of patients showed an objective antitumor response. The diverse array of nonlichenoid cutaneous irAE presented here should reflect and inform the scope of histologic patterns encountered by the practicing surgical pathologist. Such eruptions are seen in patients with a variety of underlying tumor types, many of whom ultimately demonstrate a favorable response to immune checkpoint blockade.

Original languageEnglish (US)
Pages (from-to)1381-1389
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume41
Issue number10
DOIs
StatePublished - 2017

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Keywords

  • dermatitis
  • immunotherapy
  • irAE
  • pathology
  • PD-1/PD-L1

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Kaunitz, G. J., Loss, M., Rizvi, H., Ravi, S., Cuda, J. D., Bleich, K., Esandrio, J., Sander, I., Le, D., Diaz, L. A., Brahmer, J., Drake, C. G., Hollmann, T. J., Lacouture, M. E., Hellmann, M. D., Lipson, E., & Taube, J. M. (2017). Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade: Clinicopathologic Analysis of the Nonlichenoid Histologic Pattern. American Journal of Surgical Pathology, 41(10), 1381-1389. https://doi.org/10.1097/PAS.0000000000000900