Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: Review and speculations about pathogenesis

Maryam Haque, J. Steve Hou, Katsuya Hisamichi, Koji Tamada, Carrie Ann Cusack, Mark Abdelmalek, Robert E. Brown, Eric C. Vonderheid

Research output: Contribution to journalArticle

Abstract

Cutaneous and systemic plasmacytosis (C/SP), human herpes virus-8 (HHV8), negative multicentric plasmacytic Castleman disease (MPCD), and idiopathic plasmacytic lymphadenopathy are polyclonal plasma cell proliferations of unknown etiology that predominantly affect Asian individuals. Herein, we present our experience with a Vietnamese man with typical C/SP limited to the skin but, after 10 years, may have developed perirenal involvement, and with a white man with human immunodeficiency virus and HHV8 negative MPCD with involvement of skin, lymph nodes, and kidneys at presentation, and who later succumbed to gastric carcinoma. Based on a review of the literature, we suggest that C/SP, cutaneous MPCD, and idiopathic plasmacytic lymphadenopathy with skin involvement are part of a continuum rather than distinct entities and, as such, may be regarded as variants of HHV8-negative MPCD. Although the majority of patients with C/SP run a chronic benign course, special attention should be given to monitoring for pulmonary and renal involvement. We hypothesize that long-lived plasma cells originate and survive in the environment of the skin akin to other stromal "survival" niches due to the local production of interleukin 6 and that such patients might respond to agents that interfere with interleukin-6 activity.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number6
DOIs
StatePublished - Dec 2011

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Keywords

  • Herpes virus 8
  • Interleukin-6
  • Lymphadenopathy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Haque, M., Hou, J. S., Hisamichi, K., Tamada, K., Cusack, C. A., Abdelmalek, M., Brown, R. E., & Vonderheid, E. C. (2011). Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: Review and speculations about pathogenesis. Clinical Lymphoma, Myeloma and Leukemia, 11(6), 453-461. https://doi.org/10.1016/j.clml.2011.07.004