Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease

Review and speculations about pathogenesis

Maryam Haque, J. Steve Hou, Katsuya Hisamichi, Koji Tamada, Carrie Ann Cusack, Mark Abdelmalek, Robert E. Brown, Eric C. Vonderheid

Research output: Contribution to journalArticle

Abstract

Cutaneous and systemic plasmacytosis (C/SP), human herpes virus-8 (HHV8), negative multicentric plasmacytic Castleman disease (MPCD), and idiopathic plasmacytic lymphadenopathy are polyclonal plasma cell proliferations of unknown etiology that predominantly affect Asian individuals. Herein, we present our experience with a Vietnamese man with typical C/SP limited to the skin but, after 10 years, may have developed perirenal involvement, and with a white man with human immunodeficiency virus and HHV8 negative MPCD with involvement of skin, lymph nodes, and kidneys at presentation, and who later succumbed to gastric carcinoma. Based on a review of the literature, we suggest that C/SP, cutaneous MPCD, and idiopathic plasmacytic lymphadenopathy with skin involvement are part of a continuum rather than distinct entities and, as such, may be regarded as variants of HHV8-negative MPCD. Although the majority of patients with C/SP run a chronic benign course, special attention should be given to monitoring for pulmonary and renal involvement. We hypothesize that long-lived plasma cells originate and survive in the environment of the skin akin to other stromal "survival" niches due to the local production of interleukin 6 and that such patients might respond to agents that interfere with interleukin-6 activity.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number6
DOIs
StatePublished - Dec 2011

Fingerprint

Giant Lymph Node Hyperplasia
Skin
Viruses
Plasma Cells
Interleukin-6
Kidney
Stomach
Lymph Nodes
Cell Proliferation
HIV
Carcinoma
Lung

Keywords

  • Herpes virus 8
  • Interleukin-6
  • Lymphadenopathy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease : Review and speculations about pathogenesis. / Haque, Maryam; Hou, J. Steve; Hisamichi, Katsuya; Tamada, Koji; Cusack, Carrie Ann; Abdelmalek, Mark; Brown, Robert E.; Vonderheid, Eric C.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 11, No. 6, 12.2011, p. 453-461.

Research output: Contribution to journalArticle

Haque, M, Hou, JS, Hisamichi, K, Tamada, K, Cusack, CA, Abdelmalek, M, Brown, RE & Vonderheid, EC 2011, 'Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: Review and speculations about pathogenesis', Clinical Lymphoma, Myeloma and Leukemia, vol. 11, no. 6, pp. 453-461. https://doi.org/10.1016/j.clml.2011.07.004
Haque, Maryam ; Hou, J. Steve ; Hisamichi, Katsuya ; Tamada, Koji ; Cusack, Carrie Ann ; Abdelmalek, Mark ; Brown, Robert E. ; Vonderheid, Eric C. / Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease : Review and speculations about pathogenesis. In: Clinical Lymphoma, Myeloma and Leukemia. 2011 ; Vol. 11, No. 6. pp. 453-461.
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