TY - JOUR
T1 - Current Treatment Recommendations for Correcting Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis Are Inadequate
AU - Green, Deanna
AU - Carson, Kathryn
AU - Leonard, Amanda
AU - Davis, J. Erin
AU - Rosenstein, Beryl
AU - Zeitlin, Pamela
AU - Mogayzel, Peter
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2008/10
Y1 - 2008/10
N2 - Objectives: To determine the prevalence of vitamin D deficiency (25-hydroxy vitamin D [25-OHD] levels in plasma <30 ng/mL) in pediatric patients with cystic fibrosis (CF), elucidate contributing factors for vitamin D deficiency, and determine the efficacy of ergocalciferol repletion strategies. Study design: Retrospective chart review of 262 pediatric patients from January 2003 to December 2006 with linear and logistic regression analyses. Results: Vitamin D deficiency prevalence declined in the years studied from 86.5% to 46.2%. Patients >12 years old were more likely to have deficiency than patients <5 years old (odds ratio [OR], 3.44; 95% CI, 1.73-6.84). Levels obtained in spring and summer were less likely to be deficient compared with those obatined in fall (OR, 0.24; 95% CI, 0.10-0.61; and OR, 0.25; 95% CI, 0.11-0.61; respectively). Success of treatment with 50 000 IU of ergocalciferol once, twice, or 3 times weekly was 33%, 26%, and 43%, respectively. Ergocalciferol, when compared with no treatment, did not significantly increase the proportion of patients with follow-up levels ≥30 ng/mL (χ2 P value = .80, .34, and .22, respectively). Conclusions: The prevalence of vitamin D deficiency is high, but declined with time. Age, forced expiratory volume in 1 second, and season were associated with 25-OHD levels. Despite 33% of patients responding to 50 000 IU of ergocalciferol once a week, this recommendation does not adequately treat most patients with CF who have vitamin D deficiency.
AB - Objectives: To determine the prevalence of vitamin D deficiency (25-hydroxy vitamin D [25-OHD] levels in plasma <30 ng/mL) in pediatric patients with cystic fibrosis (CF), elucidate contributing factors for vitamin D deficiency, and determine the efficacy of ergocalciferol repletion strategies. Study design: Retrospective chart review of 262 pediatric patients from January 2003 to December 2006 with linear and logistic regression analyses. Results: Vitamin D deficiency prevalence declined in the years studied from 86.5% to 46.2%. Patients >12 years old were more likely to have deficiency than patients <5 years old (odds ratio [OR], 3.44; 95% CI, 1.73-6.84). Levels obtained in spring and summer were less likely to be deficient compared with those obatined in fall (OR, 0.24; 95% CI, 0.10-0.61; and OR, 0.25; 95% CI, 0.11-0.61; respectively). Success of treatment with 50 000 IU of ergocalciferol once, twice, or 3 times weekly was 33%, 26%, and 43%, respectively. Ergocalciferol, when compared with no treatment, did not significantly increase the proportion of patients with follow-up levels ≥30 ng/mL (χ2 P value = .80, .34, and .22, respectively). Conclusions: The prevalence of vitamin D deficiency is high, but declined with time. Age, forced expiratory volume in 1 second, and season were associated with 25-OHD levels. Despite 33% of patients responding to 50 000 IU of ergocalciferol once a week, this recommendation does not adequately treat most patients with CF who have vitamin D deficiency.
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U2 - 10.1016/j.jpeds.2008.04.058
DO - 10.1016/j.jpeds.2008.04.058
M3 - Article
C2 - 18589445
AN - SCOPUS:51449122068
SN - 0022-3476
VL - 153
SP - 554-559.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -