Current treatment of adult Duchenne muscular dystrophy

Research output: Contribution to journalArticle

Abstract

Patients with Duchenne muscular dystrophy (DMD) are living longer into adulthood due to a variety of improvements in health care practices. This growing patient population presents new therapeutic challenges. In this article, we review the literature on current treatment of adult DMD as well as our own experience as a multidisciplinary team actively caring for 23 men ages 19-38 years of age. Approximately one quarter of our adult DMD patients have remained on moderate dose corticosteroids. Daily stretching exercises are recommended, particularly of the distal upper extremities. Cardiomyopathy is anticipated, detected, and treated early with afterload reduction. Oxygen saturation monitoring, noninvasive positive pressure ventilation and cough assist devices are routinely used. Other medical issues such as osteoporosis, gastrointestinal and urinary symptoms are addressed. Current and future therapies directed at prolonging the lifespan of those with DMD will result in further increases in this adult population with special needs and concerns. These needs are best addressed in a multidisciplinary clinic.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1772
Issue number2
DOIs
StatePublished - Feb 2007

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Duchenne Muscular Dystrophy
Positive-Pressure Respiration
Therapeutics
Cardiomyopathies
Cough
Upper Extremity
Population
Osteoporosis
Adrenal Cortex Hormones
Exercise
Oxygen
Delivery of Health Care
Equipment and Supplies

Keywords

  • Cardiomyopathy
  • Duchenne muscular dystrophy
  • Multidisciplinary clinic

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Biophysics

Cite this

Current treatment of adult Duchenne muscular dystrophy. / Wagner, Kathryn Rae; Lechtzin, Noah; Judge, Daniel P.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1772, No. 2, 02.2007, p. 229-237.

Research output: Contribution to journalArticle

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