Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review

Alvaro Sanabria; Pilar Pinillos; Renan B. Lira; Jatin P. Shah; Ralph P. Tufano; Mark E. Zafereo; Iain J. Nixon; Gregory W. Randolph; Ricard Simo; Vincent Vander Poorten; Alessandra Rinaldo; Jesus E. Medina; Avi Khafif; Peter Angelos; Antti A. Mäkitie; Ashok R. Shaha; Juan P. Rodrigo; Dana M. Hartl; Luiz P. Kowalski; Alfio Ferlito

doi:10.1002/hed.26883

Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review

Alvaro Sanabria, Pilar Pinillos, Renan B. Lira, Jatin P. Shah, Ralph P. Tufano, Mark E. Zafereo, Iain J. Nixon, Gregory W. Randolph, Ricard Simo, Vincent Vander Poorten, Alessandra Rinaldo, Jesus E. Medina, Avi Khafif, Peter Angelos, Antti A. Mäkitie, Ashok R. Shaha, Juan P. Rodrigo, Dana M. Hartl, Luiz P. Kowalski, Alfio Ferlito

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Most cases of thyroid carcinoma are classified as low risk. These lesions have been treated with open surgery, remote access thyroidectomy, active surveillance, and percutaneous ablation. However, there is lack of consensus and clear indications for a specific treatment selection. The objective of this study is to review the literature regarding the indications for management selection for low-risk carcinomas. Systematic review exploring inclusion and exclusion criteria used to select patients with low-risk carcinomas for treatment approaches. The search found 69 studies. The inclusion criteria most reported were nodule diameter and histopathological confirmation of the tumor type. The most common exclusions were lymph node metastasis and extra-thyroidal extension. There was significant heterogeneity among inclusion and exclusion criteria according to the analyzed therapeutic approach. Alternative therapeutic approaches in low-risk carcinomas can be cautiously considered. Open thyroidectomy remains the standard treatment against which all other approaches must be compared.

Original language	English (US)
Pages (from-to)	226-237
Number of pages	12
Journal	Head and Neck
Volume	44
Issue number	1
DOIs	https://doi.org/10.1002/hed.26883
State	Published - Jan 2022

Keywords

ablation
papillary carcinoma
surgery
surveillance
thyroid carcinoma
treatment

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26883

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Sanabria, A., Pinillos, P., Lira, R. B., Shah, J. P., Tufano, R. P., Zafereo, M. E., Nixon, I. J., Randolph, G. W., Simo, R., Vander Poorten, V., Rinaldo, A., Medina, J. E., Khafif, A., Angelos, P., Mäkitie, A. A., Shaha, A. R., Rodrigo, J. P., Hartl, D. M., Kowalski, L. P., & Ferlito, A. (2022). Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review. Head and Neck, 44(1), 226-237. https://doi.org/10.1002/hed.26883

Sanabria, A, Pinillos, P, Lira, RB, Shah, JP, Tufano, RP, Zafereo, ME, Nixon, IJ, Randolph, GW, Simo, R, Vander Poorten, V, Rinaldo, A, Medina, JE, Khafif, A, Angelos, P, Mäkitie, AA, Shaha, AR, Rodrigo, JP, Hartl, DM, Kowalski, LP & Ferlito, A 2022, 'Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review', Head and Neck, vol. 44, no. 1, pp. 226-237. https://doi.org/10.1002/hed.26883

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abstract = "Most cases of thyroid carcinoma are classified as low risk. These lesions have been treated with open surgery, remote access thyroidectomy, active surveillance, and percutaneous ablation. However, there is lack of consensus and clear indications for a specific treatment selection. The objective of this study is to review the literature regarding the indications for management selection for low-risk carcinomas. Systematic review exploring inclusion and exclusion criteria used to select patients with low-risk carcinomas for treatment approaches. The search found 69 studies. The inclusion criteria most reported were nodule diameter and histopathological confirmation of the tumor type. The most common exclusions were lymph node metastasis and extra-thyroidal extension. There was significant heterogeneity among inclusion and exclusion criteria according to the analyzed therapeutic approach. Alternative therapeutic approaches in low-risk carcinomas can be cautiously considered. Open thyroidectomy remains the standard treatment against which all other approaches must be compared.",

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author = "Alvaro Sanabria and Pilar Pinillos and Lira, {Renan B.} and Shah, {Jatin P.} and Tufano, {Ralph P.} and Zafereo, {Mark E.} and Nixon, {Iain J.} and Randolph, {Gregory W.} and Ricard Simo and {Vander Poorten}, Vincent and Alessandra Rinaldo and Medina, {Jesus E.} and Avi Khafif and Peter Angelos and M{\"a}kitie, {Antti A.} and Shaha, {Ashok R.} and Rodrigo, {Juan P.} and Hartl, {Dana M.} and Kowalski, {Luiz P.} and Alfio Ferlito",

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AU - Sanabria, Alvaro

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AU - Shah, Jatin P.

AU - Tufano, Ralph P.

AU - Zafereo, Mark E.

AU - Nixon, Iain J.

AU - Randolph, Gregory W.

AU - Simo, Ricard

AU - Vander Poorten, Vincent

AU - Rinaldo, Alessandra

AU - Medina, Jesus E.

AU - Khafif, Avi

AU - Angelos, Peter

AU - Mäkitie, Antti A.

AU - Shaha, Ashok R.

AU - Rodrigo, Juan P.

AU - Hartl, Dana M.

AU - Kowalski, Luiz P.

AU - Ferlito, Alfio

PY - 2022/1

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Current therapeutic options for low-risk papillary thyroid carcinoma: Scoping evidence review

Abstract

Keywords

ASJC Scopus subject areas

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