Current status of experimental therapeutics for prostate cancer

Chulso Moon, Jong Chul Park, Young Kwang Chae, Jin Han Yun, Saechul Kim

Research output: Contribution to journalArticle

Abstract

Hormone refractory prostate cancer (HRPC) is the progression of disease in the presence of castrate serum levels of testosterone with a median survival of approximately 1 year. A variety of strategies have been developed to improve survival for the patients with advanced prostate cancer. Despite such efforts, the effective treatment modality for those patients has not been established other than chemotherapy. New experimental therapeutics such as gene therapy, vaccine therapy and target therapy use various mechanisms to kill tumor cells selectively while sparing surrounding normal tissues. Furthermore, new approaches in the field of chemoprevention are being made. Recent data from landmark studies, in particular vaccines, have shown improvements in overall survival of HRPC patients.

Original languageEnglish (US)
Pages (from-to)116-134
Number of pages19
JournalCancer Letters
Volume266
Issue number2
DOIs
StatePublished - Aug 8 2008

Keywords

  • Gene therapy
  • Hormonal refractory prostate cancer
  • Immunotherapy
  • Targeted therapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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  • Cite this

    Moon, C., Park, J. C., Chae, Y. K., Yun, J. H., & Kim, S. (2008). Current status of experimental therapeutics for prostate cancer. Cancer Letters, 266(2), 116-134. https://doi.org/10.1016/j.canlet.2008.02.065