Current Status of Benzodiazepines

Jan Koch-Weser, David J. Greenblatt, Richard I. Shader, Darrell R. Abernethy

Research output: Contribution to journalReview articlepeer-review


Clinical Use of Benzodiazepines Anxiety Since 1977, several new benzodiazepines have been marketed in the United States for the treatment of anxiety syndromes67 68 69 70 71 (Table 1). These drugs may offer some subtle clinical options. Prazepam, for example, may cause less drowsiness after single doses than do comparable doses of other benzodiazepines because of the slow appearance of desmethyldiazepam in the blood.72 Some clinical studies suggest a reduced incidence of sedation during treatment with lorazepam and alprazolam — benzodiazepines that have an intermediate half-life — possibly because the extent of drug accumulation is reduced; however, this is not a consistent finding.69,70 In.

Original languageEnglish (US)
Pages (from-to)410-416
Number of pages7
JournalNew England Journal of Medicine
Issue number7
StatePublished - Aug 18 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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