Current standards and future directions for prostate cancer radiation therapy

Michael Pinkawa, Felix Schoth, Dirk Böhmer, Gencay Hatiboglu, Andrew Sharabi, Danny Song, Michael J. Eble

Research output: Contribution to journalReview articlepeer-review

Abstract

Definitive radiation therapy is a well-recognized curative treatment option for localized prostate cancer. A suitable technique, dose, target volume and the option of a combination with androgen deprivation therapy need to be considered. An optimal standard external beam radiotherapy currently includes intensity-modulated and image-guided radiotherapy techniques with total doses of ≥76-78 Gy in conventional fractionation. Protons or carbon ions are alternatives available only in specific centers. Data from several randomized studies increasingly support the rationale for hypofractionated radiotherapy. A simultaneous integrated boost with dose escalation focused on a computed tomography/PET-or MRI/magnetic resonance spectroscopy-detected malignant lesion is one option to increase tumor control, with potentially no additional toxicity. The application of a spacer is a promising concept for optimal protection of the rectal wall.

Original languageEnglish (US)
Pages (from-to)75-88
Number of pages14
JournalExpert Review of Anticancer Therapy
Volume13
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • PET
  • dose escalation
  • external beam radiotherapy
  • hypofractionation
  • image-guided radiotherapy
  • intensity-modulated radiotherapy
  • magnetic resonance tomography
  • prostate cancer
  • simultaneous integrated boost

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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