Current progress in pulmonary delivery of measles vaccine

Research output: Contribution to journalArticle

Abstract

Due to the high infectivity of measles virus, achieving sufficient population immunity to interrupt transmission requires two doses of live attenuated measles virus vaccine. Subcutaneous delivery of vaccine by injection requires trained personnel, maintenance of a cold chain and safe disposal of used needles and syringes. Pulmonary vaccine delivery offers the opportunity for cost-savings and improved coverage, but requires re-licensure. Two aerosol vaccine formulations, nebulized liquid and dry powder, and multiple delivery devices have been evaluated in humans and macaques. Nebulized liquid vaccine is effective for a second dose of vaccine in older children, but less effective for primary vaccination of infants. Dry powder vaccine provides solid protection in macaques and boosts responses in immune adults, but has not yet been tested in infants.

Original languageEnglish (US)
Pages (from-to)751-759
Number of pages9
JournalExpert Review of Vaccines
Volume13
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Measles Vaccine
Vaccines
Lung
Measles virus
Macaca
Powders
Attenuated Vaccines
Refrigeration
Cost Savings
Syringes
Licensure
Aerosols
Needles
Immunity
Vaccination
Maintenance
Equipment and Supplies
Injections
Population

Keywords

  • aerosol
  • dry powder
  • inhalation
  • measles virus
  • vaccine

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine
  • Medicine(all)

Cite this

Current progress in pulmonary delivery of measles vaccine. / Griffin, Diane.

In: Expert Review of Vaccines, Vol. 13, No. 6, 2014, p. 751-759.

Research output: Contribution to journalArticle

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