Current progress and questions in germline genetics of prostate cancer

William B. Isaacs, Jianfeng Xu

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. A major question exists about which additional populations of men to test, as men at all risk levels can potentially benefit by knowing their unique genetic profile of germline susceptibility variants. This article will provide a brief overview of some current issues in understanding inherited susceptibility for PCa.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalAsian Journal of Urology
Issue number1
StatePublished - Jan 2019


  • BRCA2
  • Genetic susceptibility
  • Germline genetics
  • Mutations
  • Prostate cancer
  • Single-nucleotide polymorphisms

ASJC Scopus subject areas

  • Urology


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