Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G. Mullins; David J. McGonigle; Ruth L. O'Gorman; Nicolaas A.J. Puts; Rishma Vidyasagar; C. John Evans; Richard A.E. Edden; Matthew J. Brookes; Adrian Garcia; Bradley R. Foerster; Myria Petrou; Darren Price; Bhavana S. Solanky; Inês R. Violante; Steve Williams; Martin Wilson

doi:10.1016/j.neuroimage.2012.12.004

Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G. Mullins, David J. McGonigle, Ruth L. O'Gorman, Nicolaas A.J. Puts, Rishma Vidyasagar, C. John Evans, Richard A.E. Edden, Matthew J. Brookes, Adrian Garcia, Bradley R. Foerster, Myria Petrou, Darren Price, Bhavana S. Solanky, Inês R. Violante, Steve Williams, Martin Wilson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

281 Scopus citations

Abstract

There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3. T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.

Original language	English (US)
Pages (from-to)	43-52
Number of pages	10
Journal	NeuroImage
Volume	86
DOIs	https://doi.org/10.1016/j.neuroimage.2012.12.004
State	Published - Feb 1 2014

Keywords

Edited MRS
GABA
MEGA-PRESS
MRS analysis

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1016/j.neuroimage.2012.12.004

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Mullins, P. G., McGonigle, D. J., O'Gorman, R. L., Puts, N. A. J., Vidyasagar, R., Evans, C. J., Edden, R. A. E., Brookes, M. J., Garcia, A., Foerster, B. R., Petrou, M., Price, D., Solanky, B. S., Violante, I. R., Williams, S., & Wilson, M. (2014). Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage, 86, 43-52. https://doi.org/10.1016/j.neuroimage.2012.12.004

Mullins, PG, McGonigle, DJ, O'Gorman, RL, Puts, NAJ, Vidyasagar, R, Evans, CJ, Edden, RAE, Brookes, MJ, Garcia, A, Foerster, BR, Petrou, M, Price, D, Solanky, BS, Violante, IR, Williams, S & Wilson, M 2014, 'Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA', NeuroImage, vol. 86, pp. 43-52. https://doi.org/10.1016/j.neuroimage.2012.12.004

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abstract = "There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3. T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.",

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AU - Vidyasagar, Rishma

AU - Evans, C. John

AU - Edden, Richard A.E.

AU - Brookes, Matthew J.

AU - Garcia, Adrian

AU - Foerster, Bradley R.

AU - Petrou, Myria

AU - Price, Darren

AU - Solanky, Bhavana S.

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AU - Wilson, Martin

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KW - MEGA-PRESS

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JF - NeuroImage

ER -

Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Abstract

Keywords

ASJC Scopus subject areas

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