Current Perspectives on Gastric Cancer

Juan M. Marqués-Lespier, María González-Pons, Marcia Cruz-Correa

Research output: Contribution to journalReview article

Abstract

Gastric cancer (GC) is third leading cause of cancer-related death. Only 28.3% of new GC cases survive more than 5 years. Although incidence has declined in the United States, an increase is estimated for 2016. Risk factors include sex (risk is higher in men), Helicobacter pylori infection, heredity, and lifestyle. GC is usually diagnosed between the ages of 60–80 years. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse-type GC has worse prognosis. Chemoprevention has been shown to decrease risk, but is currently not used clinically.

Original languageEnglish (US)
Pages (from-to)413-428
Number of pages16
JournalGastroenterology Clinics of North America
Volume45
Issue number3
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Keywords

  • Atrophic gastritis
  • Dysplasia
  • Gastric cancer
  • Helicobacter pylori
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Marqués-Lespier, J. M., González-Pons, M., & Cruz-Correa, M. (2016). Current Perspectives on Gastric Cancer. Gastroenterology Clinics of North America, 45(3), 413-428. https://doi.org/10.1016/j.gtc.2016.04.002