TY - JOUR
T1 - Current Methods to Define Metabolic Tumor Volume in Positron Emission Tomography
T2 - Which One is Better?
AU - Im, Hyung Jun
AU - Bradshaw, Tyler
AU - Solaiyappan, Meiyappan
AU - Cho, Steve Y.
N1 - Publisher Copyright:
© 2017, Korean Society of Nuclear Medicine.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Numerous methods to segment tumors using 18F-fluorodeoxyglucose positron emission tomography (FDG PET) have been introduced. Metabolic tumor volume (MTV) refers to the metabolically active volume of the tumor segmented using FDG PET, and has been shown to be useful in predicting patient outcome and in assessing treatment response. Also, tumor segmentation using FDG PET has useful applications in radiotherapy treatment planning. Despite extensive research on MTV showing promising results, MTV is not used in standard clinical practice yet, mainly because there is no consensus on the optimal method to segment tumors in FDG PET images. In this review, we discuss currently available methods to measure MTV using FDG PET, and assess the advantages and disadvantages of the methods.
AB - Numerous methods to segment tumors using 18F-fluorodeoxyglucose positron emission tomography (FDG PET) have been introduced. Metabolic tumor volume (MTV) refers to the metabolically active volume of the tumor segmented using FDG PET, and has been shown to be useful in predicting patient outcome and in assessing treatment response. Also, tumor segmentation using FDG PET has useful applications in radiotherapy treatment planning. Despite extensive research on MTV showing promising results, MTV is not used in standard clinical practice yet, mainly because there is no consensus on the optimal method to segment tumors in FDG PET images. In this review, we discuss currently available methods to measure MTV using FDG PET, and assess the advantages and disadvantages of the methods.
KW - F-fluorodeoxyglucose
KW - Metabolic tumor volume
KW - Positron emission tomography
KW - Segmentation
KW - Tumor
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U2 - 10.1007/s13139-017-0493-6
DO - 10.1007/s13139-017-0493-6
M3 - Review article
C2 - 29391907
AN - SCOPUS:85040902818
SN - 1869-3474
VL - 52
SP - 5
EP - 15
JO - Nuclear Medicine and Molecular Imaging
JF - Nuclear Medicine and Molecular Imaging
IS - 1
ER -