Issues related to the epidemiology, transmission, and reactivation of Pneumocystis carinii remain controversial. In this article, current studies related to geographic variations in the prevalence of P carinii pneumonia are reviewed. In addition, extensive investigations show that exposure to P carinii occurs early in life, followed by seemingly complete clearance of the organisms. Recent molecular techniques show that P carinii pneumonia during periods of immune suppression can occur either by reactivation or by acquisition of new organisms. These studies are analyzed and a composite model of P carinii infection is proposed.
|Original language||English (US)|
|Number of pages||6|
|Journal||Seminars in Respiratory Infections|
|State||Published - Dec 21 1998|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Microbiology (medical)