Current issues in the epidemiology, transmission, and reactivation of Pneumocystis carinii

W. T. Hughes

Research output: Contribution to journalReview articlepeer-review

Abstract

Issues related to the epidemiology, transmission, and reactivation of Pneumocystis carinii remain controversial. In this article, current studies related to geographic variations in the prevalence of P carinii pneumonia are reviewed. In addition, extensive investigations show that exposure to P carinii occurs early in life, followed by seemingly complete clearance of the organisms. Recent molecular techniques show that P carinii pneumonia during periods of immune suppression can occur either by reactivation or by acquisition of new organisms. These studies are analyzed and a composite model of P carinii infection is proposed.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalSeminars in Respiratory Infections
Volume13
Issue number4
StatePublished - Dec 21 1998

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)

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