Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system

Lysandra Voltaggio, Ashley M Cimino-Mathews, Justin A. Bishop, Pedram Argani, Jonathan D. Cuda, Jonathan Ira Epstein, Ralph H Hruban, George J. Netto, Mark H. Stoler, Janis M Taube, Russell S Vang, William H. Westra, Elizabeth A Montgomery

Research output: Contribution to journalReview article


Answer questions and earn CME/CNE. In this report, a team of surgical pathologists has provided a review of intraepithelial neoplasia in a host of (but not all) anatomic sites of interest to colleagues in various medical specialties, namely, uterine cervix, ovary, breast, lung, head and neck, skin, prostate, bladder, pancreas, and esophagus. There is more experience with more readily accessible sites (such as the uterine cervix and skin) than with other anatomic sites, and the lack of uniform terminology, together with divergent biology in various sites, makes it difficult to paint a unifying, relevant portrait. The authors' aim was to provide a framework from which to move forward as we care for patients with such precancerous lesions. CA Cancer J Clin 2016;66:408–436.

Original languageEnglish (US)
Pages (from-to)408-436
Number of pages29
JournalCa-A Cancer Journal for Clinicians
Issue number5
StatePublished - Sep 1 2016



  • carcinoma in situ
  • dysplasia
  • intraepithelial neoplasia
  • precancer
  • preinvasive neoplasia

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology
  • Oncology

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