TY - JOUR
T1 - Current concepts and techniques in keratoprosthesis
AU - Ilhan-Sarac, Ozge
AU - Akpek, Esen Karamursel
PY - 2005/8
Y1 - 2005/8
N2 - Purpose of review: Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance, with all estimated 10 to 15 million affected people. Although keratoplasty is by far the most successful transplantation surgery, the outcomes in high-risk adult patients, including those with ocular surface diseases and multiple graft rejections, and in pediatric patients with congenital corneal opacities are disappointing. Recent developments: Regrettably, no significant clinical developments have been achieved in the field of corneal transplantation since the introduction of steroids for graft rejection. Furthermore, obtaining donor corneal tissues and eye banking, particularly in the developing countries where corneal blindness is most prevalent, are problematic. Although the postoperative complications may be severe and limit the use of currently available devices, keratoprosthesis - artificial corneal implantation - has a role in the management of corneal blindness in carefully selected patients with complex ocular diseases who are at high risk for graft failure. Summary: This article reviews the recent ophthalmic literature published on the current concepts and techniques of keratoprosthesis surgery.
AB - Purpose of review: Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance, with all estimated 10 to 15 million affected people. Although keratoplasty is by far the most successful transplantation surgery, the outcomes in high-risk adult patients, including those with ocular surface diseases and multiple graft rejections, and in pediatric patients with congenital corneal opacities are disappointing. Recent developments: Regrettably, no significant clinical developments have been achieved in the field of corneal transplantation since the introduction of steroids for graft rejection. Furthermore, obtaining donor corneal tissues and eye banking, particularly in the developing countries where corneal blindness is most prevalent, are problematic. Although the postoperative complications may be severe and limit the use of currently available devices, keratoprosthesis - artificial corneal implantation - has a role in the management of corneal blindness in carefully selected patients with complex ocular diseases who are at high risk for graft failure. Summary: This article reviews the recent ophthalmic literature published on the current concepts and techniques of keratoprosthesis surgery.
KW - Cornea
KW - Keratoprosthesis
KW - Surgery
KW - Techniques
KW - Transplantation
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U2 - 10.1097/01.icu.0000172829.33770.d3
DO - 10.1097/01.icu.0000172829.33770.d3
M3 - Review article
C2 - 16000898
AN - SCOPUS:23044496672
SN - 1040-8738
VL - 16
SP - 246
EP - 250
JO - Current opinion in ophthalmology
JF - Current opinion in ophthalmology
IS - 4
ER -