Current and future immunosuppressive strategies in renal transplantation

Karen L. Hardinger, Matthew J. Koch, Daniel C. Brennan

Research output: Contribution to journalReview article

Abstract

The past decade has witnessed the introduction of several new immunosuppressive agents. The availability of these new pharmacologic offerings has not diminished the challenge of achieving a balance of adequate graft protection while minimizing the consequences of excessive immunosuppression. For renal transplant recipients, maintenance immunosuppression generally consists of a calcineurin inhibitor in combination with an antiproliferative agent and a corticosteroid; more recently, mammalian target of rapamycin inhibitors have been used. Excellent results have been achieved at many transplant centers with combinations of these agents in a variety of protocols. Regimens designed to limit or eliminate calcineurin inhibitor and/or corticosteroid therapy are actively being pursued in the transplant community. Allograft tolerance and xenotransplantation are being studied, and the knowledge gained from the effort may help in the development of innovative strategies and new immunosuppressive agents.

Original languageEnglish (US)
Pages (from-to)1159-1176
Number of pages18
JournalPharmacotherapy
Volume24
Issue number9
DOIs
StatePublished - Sep 4 2004
Externally publishedYes

Keywords

  • Antibodies
  • Antiproliferative agents
  • Corticosteroids
  • Immunophilin-binding agents
  • Immunosuppression
  • Mammalian target of rapamycin inhibitors
  • Renal transplantation

ASJC Scopus subject areas

  • Pharmacology (medical)

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