Current and future applications of SAGE to cardiovascular medicine

Willmar D. Patino, Omar Y. Mian, Yukitaka Shizukuda, Paul M. Hwang

Research output: Contribution to journalReview articlepeer-review

Abstract

The recently sequenced mammalian genomes represent unprecedented resources for advancing our understanding of human diseases. Characterizing gene expression is an important step in translating genomic sequences into clinically useful information. Currently, gene expression studies are revolutionizing the approaches taken to address both basic science and clinical questions. Two major methods have emerged for the global examination of the transcriptome: microarrays and Serial Analysis of Gene Expression (SAGE). The SAGE technique comprehensively maps gene transcription by using the genomic database, yet it remains relatively underutilized for studying cardiovascular biology. This review describes current cardiovascular studies using the SAGE technique and outlines some potential strategies for employing this powerful tool to further our understanding of the cardiovascular system in health and in disease.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume13
Issue number4
DOIs
StatePublished - May 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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