TY - JOUR
T1 - Current Advances in Chronic Kidney Disease in Children
T2 - Growth, Cardiovascular, and Neurocognitive Risk Factors
AU - Greenbaum, Larry A.
AU - Warady, Bradley A.
AU - Furth, Susan L.
PY - 2009/7
Y1 - 2009/7
N2 - Linear growth and neurocognitive development are two of the most important differences between adults and children, in terms of clinical issues that must be addressed in patients with chronic kidney disease (CKD). Correction of metabolic acidosis, nutritional deficiency, and renal osteodystrophy improve linear growth, but many children require administration of growth hormone to achieve normal growth. A variety of neurocognitive deficits occur in children with CKD, although there has been an improvement in outcome via improved dialysis, correction of malnutrition, and decreased aluminum exposure. Although growth and neurocognitive development are delayed, cardiovascular complications are accelerated in children with CKD, and are reflected in a dramatic increase in cardiovascular mortality compared with healthy children. Other early cardiovascular complications in children with CKD include left ventricular hypertrophy, cardiac dysfunction, and vascular calcifications.
AB - Linear growth and neurocognitive development are two of the most important differences between adults and children, in terms of clinical issues that must be addressed in patients with chronic kidney disease (CKD). Correction of metabolic acidosis, nutritional deficiency, and renal osteodystrophy improve linear growth, but many children require administration of growth hormone to achieve normal growth. A variety of neurocognitive deficits occur in children with CKD, although there has been an improvement in outcome via improved dialysis, correction of malnutrition, and decreased aluminum exposure. Although growth and neurocognitive development are delayed, cardiovascular complications are accelerated in children with CKD, and are reflected in a dramatic increase in cardiovascular mortality compared with healthy children. Other early cardiovascular complications in children with CKD include left ventricular hypertrophy, cardiac dysfunction, and vascular calcifications.
KW - Chronic kidney failure
KW - cardiovascular diseases
KW - developmental disabilities
KW - human growth hormone
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U2 - 10.1016/j.semnephrol.2009.03.017
DO - 10.1016/j.semnephrol.2009.03.017
M3 - Article
C2 - 19615563
AN - SCOPUS:67650150956
SN - 0270-9295
VL - 29
SP - 425
EP - 434
JO - Seminars in Nephrology
JF - Seminars in Nephrology
IS - 4
ER -