TY - JOUR
T1 - Curious entanglements
T2 - interactions between mosquitoes, their microbiota, and arboviruses
AU - Caragata, Eric P.
AU - Tikhe, Chinmay V.
AU - Dimopoulos, George
N1 - Funding Information:
EPC, CVT, and GD were supported by the National Institutes of Health grants R01AI141532 , R01AI122743 , R01AI121253 , R21AI131574 and R21AI136456 , and a postdoctoral fellowship from the Johns Hopkins Malaria Research Institute to CVT.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/8
Y1 - 2019/8
N2 - Mosquitoes naturally harbor a diverse community of microorganisms that play a crucial role in their biology. Mosquito–microbiota interactions are abundant and complex. They can dramatically alter the mosquito immune response, and impede or enhance a mosquito's ability to transmit medically important arboviral pathogens. Yet critically, given the massive public health impact of arboviral disease, few such interactions have been well characterized. In this review, we describe the current state of knowledge of the role of microorganisms in mosquito biology, how microbial-induced changes to mosquito immunity moderate infection with arboviruses, cases of mosquito–microbial–virus interactions with a defined mechanism, and the molecular interactions that underlie the endosymbiotic bacterium Wolbachia's ability to block virus infection in mosquitoes.
AB - Mosquitoes naturally harbor a diverse community of microorganisms that play a crucial role in their biology. Mosquito–microbiota interactions are abundant and complex. They can dramatically alter the mosquito immune response, and impede or enhance a mosquito's ability to transmit medically important arboviral pathogens. Yet critically, given the massive public health impact of arboviral disease, few such interactions have been well characterized. In this review, we describe the current state of knowledge of the role of microorganisms in mosquito biology, how microbial-induced changes to mosquito immunity moderate infection with arboviruses, cases of mosquito–microbial–virus interactions with a defined mechanism, and the molecular interactions that underlie the endosymbiotic bacterium Wolbachia's ability to block virus infection in mosquitoes.
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U2 - 10.1016/j.coviro.2019.05.005
DO - 10.1016/j.coviro.2019.05.005
M3 - Review article
C2 - 31176069
AN - SCOPUS:85066476004
SN - 1879-6257
VL - 37
SP - 26
EP - 36
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -