Cure of cryptococcal infection during continued immunosuppressive therapy

A. J. Watson, R. P. Russell, R. F. Cabreja, R. Braverman, A. Whelton

Research output: Contribution to journalArticle

Abstract

Cryptococcus neoformans is a significant pathogen in immunosuppressed patients. In renal transplant recipients receiving prednisone, the development of cryptococcosis is associated with a poor prognosis. When such patients develop cryptococcosis they pose a particularly difficult clinical dilemma since withdrawal of prednisone, to facilitate cure of their fungal infection, may predispose to loss of their transplanted kidney. We report our experience with cryptococcal infection in 13 renal transplant patients. In 11 of these patients maintenance immunosuppres-sion was cautiously continued to preserve allograft function. The results of our study suggest that maintenance immunosuppressive therapy may be continued throughout the period of anti-fungal therapy and does not preclude eradication of the infecting organisms. Our experience indicates that the prognosis for the renal transplant patient who has cryptococcosis can be improved.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalQJM
Volume55
Issue number2
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Medicine(all)

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    Watson, A. J., Russell, R. P., Cabreja, R. F., Braverman, R., & Whelton, A. (1985). Cure of cryptococcal infection during continued immunosuppressive therapy. QJM, 55(2), 169-172. https://doi.org/10.1093/oxfordjournals.qjmed.a067864