Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C. Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Original languageEnglish (US)
Article number525
Journalecancermedicalscience
Volume9
DOIs
StatePublished - Apr 22 2015
Externally publishedYes

Keywords

  • Activator protein-1 (ap-1)
  • Curcumin
  • Human papilloma virus (hpa)
  • Nuclear factor kappab (nf-kb)
  • Transcription

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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