Curative therapy for bladder cancer in routine clinical practice: A population-based outcomes study

C. M. Booth, D. R. Siemens, G. Li, Y. Peng, W. Kong, D. M. Berman, W. J. Mackillop

Research output: Contribution to journalArticle

Abstract

Aims: Definitive therapy of bladder cancer involves cystectomy or radiotherapy; controversy exists regarding optimal management. Here we describe the management and outcomes of patients treated in routine practice. Materials and methods: Treatment records were linked to the Ontario Cancer Registry to identify all cases of bladder cancer in Ontario treated with cystectomy or radiotherapy in 1994-2008. Practice patterns are described in three study periods: 1994-1998, 1999-2003, 2004-2008. Logistic regression, Cox model and propensity score analyses were used to evaluate factors associated with treatment choice and survival. Results: In total, 3879 cases (74%) underwent cystectomy and 1380 (26%) were treated with primary radiotherapy. Cystectomy use increased over time (66, 75, 78%), whereas radiotherapy decreased (34, 25, 22%), P

Original languageEnglish (US)
Pages (from-to)506-514
Number of pages9
JournalClinical Oncology
Volume26
Issue number8
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Bladder cancer
  • Cystectomy
  • Health services
  • Outcomes
  • Quality of care
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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    Booth, C. M., Siemens, D. R., Li, G., Peng, Y., Kong, W., Berman, D. M., & Mackillop, W. J. (2014). Curative therapy for bladder cancer in routine clinical practice: A population-based outcomes study. Clinical Oncology, 26(8), 506-514. https://doi.org/10.1016/j.clon.2014.05.007