TY - JOUR
T1 - Curative Resection of Adrenocortical Carcinoma
T2 - Rates and Patterns of Postoperative Recurrence
AU - Amini, Neda
AU - Margonis, Georgios Antonios
AU - Kim, Yuhree
AU - Tran, Thuy B.
AU - Postlewait, Lauren M.
AU - Maithel, Shishir K.
AU - Wang, Tracy S.
AU - Evans, Douglas B.
AU - Hatzaras, Ioannis
AU - Shenoy, Rivfka
AU - Phay, John E.
AU - Keplinger, Kara
AU - Fields, Ryan C.
AU - Jin, Linda X.
AU - Weber, Sharon M.
AU - Salem, Ahmed
AU - Sicklick, Jason K.
AU - Gad, Shady
AU - Yopp, Adam C.
AU - Mansour, John C.
AU - Duh, Quan Yang
AU - Seiser, Natalie
AU - Solorzano, Carmen C.
AU - Kiernan, Colleen M.
AU - Votanopoulos, Konstantinos I.
AU - Levine, Edward A.
AU - Poultsides, George A.
AU - Pawlik, Timothy M.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Adrenocortical carcinoma (ACC) is a rare malignancy. The aim of this study was to determine the incidence and patterns of recurrence after curative-intent surgery for ACC. Methods: Patients who underwent curative-intent resection for ACC between 1993 and 2014 were identified from 13 academic institutions participating in the United States ACC study group. Patients with metastasis or an R2 margin were excluded. Patterns and rates of recurrence were determined and classified as locoregional and distant recurrence. Results: A total of 180 patients with a median age of 52 years (interquartile range 43–61) were identified. Most patients underwent open surgery (n = 111, 64.5 %) and had an R0 resection margin (n = 117, 75.0 %). At last follow-up, 116 patients (64.4 %) had experienced recurrence (locoregional only, n = 41, 36.3 %; distant only, n = 51, 45.1 %; locoregional and distant, n = 21, 18.6 %). Median time to recurrence was 18.8 months. Several factors were associated with locoregional recurrence, including left-sided ACC location (odds ratio [OR] 2.71, 95 % confidence interval [CI] 1.06–6.89) and T3/T4 disease (reference T1/T2, OR 3.04, 95 % CI 1.19–7.80) (both p
AB - Background: Adrenocortical carcinoma (ACC) is a rare malignancy. The aim of this study was to determine the incidence and patterns of recurrence after curative-intent surgery for ACC. Methods: Patients who underwent curative-intent resection for ACC between 1993 and 2014 were identified from 13 academic institutions participating in the United States ACC study group. Patients with metastasis or an R2 margin were excluded. Patterns and rates of recurrence were determined and classified as locoregional and distant recurrence. Results: A total of 180 patients with a median age of 52 years (interquartile range 43–61) were identified. Most patients underwent open surgery (n = 111, 64.5 %) and had an R0 resection margin (n = 117, 75.0 %). At last follow-up, 116 patients (64.4 %) had experienced recurrence (locoregional only, n = 41, 36.3 %; distant only, n = 51, 45.1 %; locoregional and distant, n = 21, 18.6 %). Median time to recurrence was 18.8 months. Several factors were associated with locoregional recurrence, including left-sided ACC location (odds ratio [OR] 2.71, 95 % confidence interval [CI] 1.06–6.89) and T3/T4 disease (reference T1/T2, OR 3.04, 95 % CI 1.19–7.80) (both p
UR - http://www.scopus.com/inward/record.url?scp=84952630840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952630840&partnerID=8YFLogxK
U2 - 10.1245/s10434-015-4810-y
DO - 10.1245/s10434-015-4810-y
M3 - Article
C2 - 26282907
AN - SCOPUS:84952630840
SN - 1068-9265
VL - 23
SP - 126
EP - 133
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 1
ER -