TY - JOUR
T1 - Curative cerebrovascular reconstruction with the Pipeline embolization device
T2 - The emergence of definitive endovascular therapy for intracranial aneurysms
AU - Fiorella, D.
AU - Lylyk, P.
AU - Szikora, I.
AU - Kelly, M. E.
AU - Albuquerque, F. C.
AU - McDougall, C. G.
AU - Nelson, P. K.
PY - 2009/7
Y1 - 2009/7
N2 - Endovascular, endosaccular, coil embolization has emerged as an established therapy for both ruptured and unruptured cerebral aneurysms. However, many aneurysms are not cured using conventional endovascular techniques. Coil embolization often results in incomplete aneurysm occlusion or recanalization in the ensuing months after treatment. The Pipeline embolization device (PED; Chestnut Medical) represents a new generation endoluminal implant which is designed to treat aneurysms by reconstructing the diseased parent artery. Immediately after implantation, the PED functions to divert flow from the aneurysm, creating an environment conducive to thrombosis. With time, the PED is incorporated into the vessel wall as neointimal - endothelial overgrowth occurs along the construct. Ultimately, this process results in the durable complete exclusion of the aneurysm from the cerebrovasculature and a definitive endoluminal reconstruction of the diseased parent artery.
AB - Endovascular, endosaccular, coil embolization has emerged as an established therapy for both ruptured and unruptured cerebral aneurysms. However, many aneurysms are not cured using conventional endovascular techniques. Coil embolization often results in incomplete aneurysm occlusion or recanalization in the ensuing months after treatment. The Pipeline embolization device (PED; Chestnut Medical) represents a new generation endoluminal implant which is designed to treat aneurysms by reconstructing the diseased parent artery. Immediately after implantation, the PED functions to divert flow from the aneurysm, creating an environment conducive to thrombosis. With time, the PED is incorporated into the vessel wall as neointimal - endothelial overgrowth occurs along the construct. Ultimately, this process results in the durable complete exclusion of the aneurysm from the cerebrovasculature and a definitive endoluminal reconstruction of the diseased parent artery.
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U2 - 10.1136/jnis.2009.000083
DO - 10.1136/jnis.2009.000083
M3 - Review article
C2 - 21994109
AN - SCOPUS:77949392782
SN - 1759-8478
VL - 1
SP - 56
EP - 65
JO - Journal of neurointerventional surgery
JF - Journal of neurointerventional surgery
IS - 1
ER -