Cunninghamella echinulata causing fatally invasive fungal sinusitis

Robert E. LeBlanc, Zina Meriden, Deanna A. Sutton, Elizabeth H. Thompson, Dionissios Neofytos, Sean Xiang Zhang

Research output: Contribution to journalArticle

Abstract

We report a fatal case of invasive fungal sinusitis caused by Cunninghamella echinulata in a febrile, neutropenic 15-year-old male with relapsing acute leukemia. The isolate was recovered from a nasal biopsy from the right middle meatus, and microscopic examination of the tissue revealed angioinvasion and necrosis. Human infection caused by this organism has not been well documented; however, this report alerts us to its life-threatening potential.

Original languageEnglish (US)
Pages (from-to)506-509
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume76
Issue number4
DOIs
StatePublished - Aug 2013

Fingerprint

Cunninghamella
Sinusitis
Nose
Leukemia
Fever
Necrosis
Biopsy
Infection

Keywords

  • Angioinvasion
  • Cunninghamella
  • Cunninghamella echinulata
  • Febrile neutropenia
  • Filamentous fungi
  • Invasive fungal infection
  • Leukemia
  • Sinusitis
  • Zygomycetes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cunninghamella echinulata causing fatally invasive fungal sinusitis. / LeBlanc, Robert E.; Meriden, Zina; Sutton, Deanna A.; Thompson, Elizabeth H.; Neofytos, Dionissios; Zhang, Sean Xiang.

In: Diagnostic Microbiology and Infectious Disease, Vol. 76, No. 4, 08.2013, p. 506-509.

Research output: Contribution to journalArticle

LeBlanc, Robert E. ; Meriden, Zina ; Sutton, Deanna A. ; Thompson, Elizabeth H. ; Neofytos, Dionissios ; Zhang, Sean Xiang. / Cunninghamella echinulata causing fatally invasive fungal sinusitis. In: Diagnostic Microbiology and Infectious Disease. 2013 ; Vol. 76, No. 4. pp. 506-509.
@article{3410ceb9c2914e51971cc051cb5af4c7,
title = "Cunninghamella echinulata causing fatally invasive fungal sinusitis",
abstract = "We report a fatal case of invasive fungal sinusitis caused by Cunninghamella echinulata in a febrile, neutropenic 15-year-old male with relapsing acute leukemia. The isolate was recovered from a nasal biopsy from the right middle meatus, and microscopic examination of the tissue revealed angioinvasion and necrosis. Human infection caused by this organism has not been well documented; however, this report alerts us to its life-threatening potential.",
keywords = "Angioinvasion, Cunninghamella, Cunninghamella echinulata, Febrile neutropenia, Filamentous fungi, Invasive fungal infection, Leukemia, Sinusitis, Zygomycetes",
author = "LeBlanc, {Robert E.} and Zina Meriden and Sutton, {Deanna A.} and Thompson, {Elizabeth H.} and Dionissios Neofytos and Zhang, {Sean Xiang}",
year = "2013",
month = "8",
doi = "10.1016/j.diagmicrobio.2013.03.009",
language = "English (US)",
volume = "76",
pages = "506--509",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Cunninghamella echinulata causing fatally invasive fungal sinusitis

AU - LeBlanc, Robert E.

AU - Meriden, Zina

AU - Sutton, Deanna A.

AU - Thompson, Elizabeth H.

AU - Neofytos, Dionissios

AU - Zhang, Sean Xiang

PY - 2013/8

Y1 - 2013/8

N2 - We report a fatal case of invasive fungal sinusitis caused by Cunninghamella echinulata in a febrile, neutropenic 15-year-old male with relapsing acute leukemia. The isolate was recovered from a nasal biopsy from the right middle meatus, and microscopic examination of the tissue revealed angioinvasion and necrosis. Human infection caused by this organism has not been well documented; however, this report alerts us to its life-threatening potential.

AB - We report a fatal case of invasive fungal sinusitis caused by Cunninghamella echinulata in a febrile, neutropenic 15-year-old male with relapsing acute leukemia. The isolate was recovered from a nasal biopsy from the right middle meatus, and microscopic examination of the tissue revealed angioinvasion and necrosis. Human infection caused by this organism has not been well documented; however, this report alerts us to its life-threatening potential.

KW - Angioinvasion

KW - Cunninghamella

KW - Cunninghamella echinulata

KW - Febrile neutropenia

KW - Filamentous fungi

KW - Invasive fungal infection

KW - Leukemia

KW - Sinusitis

KW - Zygomycetes

UR - http://www.scopus.com/inward/record.url?scp=84880729141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880729141&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2013.03.009

DO - 10.1016/j.diagmicrobio.2013.03.009

M3 - Article

C2 - 23602784

AN - SCOPUS:84880729141

VL - 76

SP - 506

EP - 509

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

IS - 4

ER -