Cumulative tenofovir disoproxil fumarate exposure is associated with biomarkers of tubular injury and fibrosis in HIV-infected men

Vasantha Jotwani, Rebecca Scherzer, Michelle M. Estrella, Lisa P. Jacobson, Mallory D. Witt, Frank Palella, Bernard MacAtangay, Michael Bennett, Chirag R. Parikh, Joachim H. Ix, Michael Shlipak

Research output: Contribution to journalArticlepeer-review

Abstract

Tenofovir disoproxil fumarate (TDF) can cause kidney damage, but current clinical tests are insensitive for detecting toxicity. Among 884 HIV-infected men enrolled in the Multicenter AIDS Cohort Study, we measured urine biomarkers specific for tubular damage (interleukin-18, kidney injury molecule-1, procollagen type III Nterminal propeptide) and albuminuria. In adjusted analyses, each year of TDF exposure was independently associated with 3.3% higher interleukin-18 (95% CI: 0.8% to 5.8%), 3.4% higher kidney injury molecule-1 (1.1% to 5.7%), and 3.1% higher procollagen type III Nterminal propeptide (0.8% to 5.5%), but not with albuminuria (2.8%; -0.6% to 6.2%). Biomarkers of tubular damage may be more sensitive than albuminuria for detecting toxicity from TDF and other medications.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of acquired immune deficiency syndromes
Volume73
Issue number2
DOIs
StatePublished - Oct 1 2016

Keywords

  • Biomarker
  • Kidney
  • Nephrotoxicity
  • Tenofovir disoproxil fumarate

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cumulative tenofovir disoproxil fumarate exposure is associated with biomarkers of tubular injury and fibrosis in HIV-infected men'. Together they form a unique fingerprint.

Cite this