Cumulative lead dose and cognitive function in older adults

Karen J Bandeen Roche, Thomas A. Glass, Karen I Bolla, Andrew C. Todd, Brian S Schwartz

Research output: Contribution to journalArticle

Abstract

Background: The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility of adverse cognitive outcomes. We evaluated whether cumulative lead dose from environmental exposures is associated with cognitive function and decline, and whether such effects are persistent, reversible, or progressive. Methods: We used longitudinal linear modeling to evaluate associations of tibia lead concentration with cognitive function and decline in sociodemographically diverse, community-dwelling adults aged 50-70 years who were randomly selected from neighborhoods in Baltimore. Six summary measures of cognitive function were created from standard tests in the following domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, and visual memory. Results: The mean (SD) tibia lead level was 18.8 (11.6) μg/g. In models adjusted for demographic characteristics, socioeconomic status (SES), and race/ethnicity, higher tibia lead was associated with a progressive decline in eye-hand coordination. Tibia lead was associated with persistently impaired cognitive function in all 6 domains, although these associations weakened after increasing covariate control. In fully adjusted stratified analysis among white persons, persistent effects were apparent in eye-hand coordination, executive functioning, and verbal memory and learning. Conclusions: The study presents the strongest evidence to date of the effects of cumulative lead dose on adult cognitive function independent of SES. The study population was relatively young and the average total duration of follow-up short (

Original languageEnglish (US)
Pages (from-to)831-839
Number of pages9
JournalEpidemiology
Volume20
Issue number6
DOIs
StatePublished - Nov 2009

Fingerprint

Cognition
Tibia
Verbal Learning
Hand
Social Class
Independent Living
Baltimore
Environmental Exposure
Population
Lead
Language
Demography
Cognitive Dysfunction

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cumulative lead dose and cognitive function in older adults. / Bandeen Roche, Karen J; Glass, Thomas A.; Bolla, Karen I; Todd, Andrew C.; Schwartz, Brian S.

In: Epidemiology, Vol. 20, No. 6, 11.2009, p. 831-839.

Research output: Contribution to journalArticle

@article{8713520b3f294672b1ff9e43c1d34304,
title = "Cumulative lead dose and cognitive function in older adults",
abstract = "Background: The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility of adverse cognitive outcomes. We evaluated whether cumulative lead dose from environmental exposures is associated with cognitive function and decline, and whether such effects are persistent, reversible, or progressive. Methods: We used longitudinal linear modeling to evaluate associations of tibia lead concentration with cognitive function and decline in sociodemographically diverse, community-dwelling adults aged 50-70 years who were randomly selected from neighborhoods in Baltimore. Six summary measures of cognitive function were created from standard tests in the following domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, and visual memory. Results: The mean (SD) tibia lead level was 18.8 (11.6) μg/g. In models adjusted for demographic characteristics, socioeconomic status (SES), and race/ethnicity, higher tibia lead was associated with a progressive decline in eye-hand coordination. Tibia lead was associated with persistently impaired cognitive function in all 6 domains, although these associations weakened after increasing covariate control. In fully adjusted stratified analysis among white persons, persistent effects were apparent in eye-hand coordination, executive functioning, and verbal memory and learning. Conclusions: The study presents the strongest evidence to date of the effects of cumulative lead dose on adult cognitive function independent of SES. The study population was relatively young and the average total duration of follow-up short (",
author = "{Bandeen Roche}, {Karen J} and Glass, {Thomas A.} and Bolla, {Karen I} and Todd, {Andrew C.} and Schwartz, {Brian S}",
year = "2009",
month = "11",
doi = "10.1097/EDE.0b013e3181b5f100",
language = "English (US)",
volume = "20",
pages = "831--839",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Cumulative lead dose and cognitive function in older adults

AU - Bandeen Roche, Karen J

AU - Glass, Thomas A.

AU - Bolla, Karen I

AU - Todd, Andrew C.

AU - Schwartz, Brian S

PY - 2009/11

Y1 - 2009/11

N2 - Background: The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility of adverse cognitive outcomes. We evaluated whether cumulative lead dose from environmental exposures is associated with cognitive function and decline, and whether such effects are persistent, reversible, or progressive. Methods: We used longitudinal linear modeling to evaluate associations of tibia lead concentration with cognitive function and decline in sociodemographically diverse, community-dwelling adults aged 50-70 years who were randomly selected from neighborhoods in Baltimore. Six summary measures of cognitive function were created from standard tests in the following domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, and visual memory. Results: The mean (SD) tibia lead level was 18.8 (11.6) μg/g. In models adjusted for demographic characteristics, socioeconomic status (SES), and race/ethnicity, higher tibia lead was associated with a progressive decline in eye-hand coordination. Tibia lead was associated with persistently impaired cognitive function in all 6 domains, although these associations weakened after increasing covariate control. In fully adjusted stratified analysis among white persons, persistent effects were apparent in eye-hand coordination, executive functioning, and verbal memory and learning. Conclusions: The study presents the strongest evidence to date of the effects of cumulative lead dose on adult cognitive function independent of SES. The study population was relatively young and the average total duration of follow-up short (

AB - Background: The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility of adverse cognitive outcomes. We evaluated whether cumulative lead dose from environmental exposures is associated with cognitive function and decline, and whether such effects are persistent, reversible, or progressive. Methods: We used longitudinal linear modeling to evaluate associations of tibia lead concentration with cognitive function and decline in sociodemographically diverse, community-dwelling adults aged 50-70 years who were randomly selected from neighborhoods in Baltimore. Six summary measures of cognitive function were created from standard tests in the following domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, and visual memory. Results: The mean (SD) tibia lead level was 18.8 (11.6) μg/g. In models adjusted for demographic characteristics, socioeconomic status (SES), and race/ethnicity, higher tibia lead was associated with a progressive decline in eye-hand coordination. Tibia lead was associated with persistently impaired cognitive function in all 6 domains, although these associations weakened after increasing covariate control. In fully adjusted stratified analysis among white persons, persistent effects were apparent in eye-hand coordination, executive functioning, and verbal memory and learning. Conclusions: The study presents the strongest evidence to date of the effects of cumulative lead dose on adult cognitive function independent of SES. The study population was relatively young and the average total duration of follow-up short (

UR - http://www.scopus.com/inward/record.url?scp=74549123304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74549123304&partnerID=8YFLogxK

U2 - 10.1097/EDE.0b013e3181b5f100

DO - 10.1097/EDE.0b013e3181b5f100

M3 - Article

C2 - 19752734

AN - SCOPUS:74549123304

VL - 20

SP - 831

EP - 839

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 6

ER -