Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study

S. Shoptaw, R. Stall, J. Bordon, U. Kao, C. Cox, X. Li, D. G. Ostrow, M. W. Plankey

Research output: Contribution to journalArticlepeer-review

Abstract

We examined associations between stimulant use (methamphetamine and cocaine) and other substances (nicotine, marijuana, alcohol and inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV {thorn}) men taking highly active antiretroviral therapy (ART) and HIV-seronegative (HIV2) men in the Multicenter AIDS Cohort Study. Among HIV {thorn} men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent ART use), and recent cohort enrolment (1.38; 95% CI: 1.24, 1.55) were multiplicatively associated with increase in CD4+/CD8+ ratios. Cumulative use of methamphetamine (0.93; 95% CI: 0.88, 0.98, per 10 use-years), cocaine (0.93; 95% CI: 0.89, 0.96, per 10 use-years) and cumulative medical visits (0.99; 95% CI: 0.98, 0.99, per 10 visit-years), each showed small negative associations with CD4+/CD8+ ratios. Among HIV2 men, cumulative medical visits (0.996; 95% CI: 0.993, 0.999), cumulative number of male sexual partners (0.999; 95% CI: 0.998, 0.9998, per 10 partner-years) and cigarette pack-years (1.10; 95% CI: 1.02, 1.18, per 10 pack-years) were associated with CD4+/CD8+ ratios over the same period. ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV{thorn} men who engage in stimulant use.

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalInternational Journal of STD and AIDS
Volume23
Issue number8
DOIs
StatePublished - Aug 2012

Keywords

  • Adherence
  • Antiretroviral therapy
  • CD4+/CD8+ ratio
  • Cocaine
  • HIV
  • Men
  • Methamphetamine
  • Multicenter AIDS Cohort Study

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study'. Together they form a unique fingerprint.

Cite this