Abstract
We examined associations between stimulant use (methamphetamine and cocaine) and other substances (nicotine, marijuana, alcohol and inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV {thorn}) men taking highly active antiretroviral therapy (ART) and HIV-seronegative (HIV2) men in the Multicenter AIDS Cohort Study. Among HIV {thorn} men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent ART use), and recent cohort enrolment (1.38; 95% CI: 1.24, 1.55) were multiplicatively associated with increase in CD4+/CD8+ ratios. Cumulative use of methamphetamine (0.93; 95% CI: 0.88, 0.98, per 10 use-years), cocaine (0.93; 95% CI: 0.89, 0.96, per 10 use-years) and cumulative medical visits (0.99; 95% CI: 0.98, 0.99, per 10 visit-years), each showed small negative associations with CD4+/CD8+ ratios. Among HIV2 men, cumulative medical visits (0.996; 95% CI: 0.993, 0.999), cumulative number of male sexual partners (0.999; 95% CI: 0.998, 0.9998, per 10 partner-years) and cigarette pack-years (1.10; 95% CI: 1.02, 1.18, per 10 pack-years) were associated with CD4+/CD8+ ratios over the same period. ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV{thorn} men who engage in stimulant use.
Original language | English (US) |
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Pages (from-to) | 576-580 |
Number of pages | 5 |
Journal | International Journal of STD and AIDS |
Volume | 23 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2012 |
Keywords
- Adherence
- Antiretroviral therapy
- CD4+/CD8+ ratio
- Cocaine
- HIV
- Men
- Methamphetamine
- Multicenter AIDS Cohort Study
ASJC Scopus subject areas
- Dermatology
- Public Health, Environmental and Occupational Health
- Infectious Diseases
- Pharmacology (medical)