Abstract
We examined associations between stimulant use (methamphetamine and cocaine) and other substances (nicotine, marijuana, alcohol and inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV {thorn}) men taking highly active antiretroviral therapy (ART) and HIV-seronegative (HIV2) men in the Multicenter AIDS Cohort Study. Among HIV {thorn} men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent ART use), and recent cohort enrolment (1.38; 95% CI: 1.24, 1.55) were multiplicatively associated with increase in CD4+/CD8+ ratios. Cumulative use of methamphetamine (0.93; 95% CI: 0.88, 0.98, per 10 use-years), cocaine (0.93; 95% CI: 0.89, 0.96, per 10 use-years) and cumulative medical visits (0.99; 95% CI: 0.98, 0.99, per 10 visit-years), each showed small negative associations with CD4+/CD8+ ratios. Among HIV2 men, cumulative medical visits (0.996; 95% CI: 0.993, 0.999), cumulative number of male sexual partners (0.999; 95% CI: 0.998, 0.9998, per 10 partner-years) and cigarette pack-years (1.10; 95% CI: 1.02, 1.18, per 10 pack-years) were associated with CD4+/CD8+ ratios over the same period. ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV{thorn} men who engage in stimulant use.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 576-580 |
| Number of pages | 5 |
| Journal | International Journal of STD and AIDS |
| Volume | 23 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2012 |
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Keywords
- Adherence
- Antiretroviral therapy
- CD4+/CD8+ ratio
- Cocaine
- HIV
- Men
- Methamphetamine
- Multicenter AIDS Cohort Study
ASJC Scopus subject areas
- Dermatology
- Public Health, Environmental and Occupational Health
- Pharmacology (medical)
- Infectious Diseases
Cite this
Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study. / Shoptaw, S.; Stall, R.; Bordon, J.; Kao, U.; Cox, Christopher; Li, Xiuhong; Ostrow, D. G.; Plankey, M. W.
In: International Journal of STD and AIDS, Vol. 23, No. 8, 08.2012, p. 576-580.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study
AU - Shoptaw, S.
AU - Stall, R.
AU - Bordon, J.
AU - Kao, U.
AU - Cox, Christopher
AU - Li, Xiuhong
AU - Ostrow, D. G.
AU - Plankey, M. W.
PY - 2012/8
Y1 - 2012/8
N2 - We examined associations between stimulant use (methamphetamine and cocaine) and other substances (nicotine, marijuana, alcohol and inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV {thorn}) men taking highly active antiretroviral therapy (ART) and HIV-seronegative (HIV2) men in the Multicenter AIDS Cohort Study. Among HIV {thorn} men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent ART use), and recent cohort enrolment (1.38; 95% CI: 1.24, 1.55) were multiplicatively associated with increase in CD4+/CD8+ ratios. Cumulative use of methamphetamine (0.93; 95% CI: 0.88, 0.98, per 10 use-years), cocaine (0.93; 95% CI: 0.89, 0.96, per 10 use-years) and cumulative medical visits (0.99; 95% CI: 0.98, 0.99, per 10 visit-years), each showed small negative associations with CD4+/CD8+ ratios. Among HIV2 men, cumulative medical visits (0.996; 95% CI: 0.993, 0.999), cumulative number of male sexual partners (0.999; 95% CI: 0.998, 0.9998, per 10 partner-years) and cigarette pack-years (1.10; 95% CI: 1.02, 1.18, per 10 pack-years) were associated with CD4+/CD8+ ratios over the same period. ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV{thorn} men who engage in stimulant use.
AB - We examined associations between stimulant use (methamphetamine and cocaine) and other substances (nicotine, marijuana, alcohol and inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV {thorn}) men taking highly active antiretroviral therapy (ART) and HIV-seronegative (HIV2) men in the Multicenter AIDS Cohort Study. Among HIV {thorn} men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent ART use), and recent cohort enrolment (1.38; 95% CI: 1.24, 1.55) were multiplicatively associated with increase in CD4+/CD8+ ratios. Cumulative use of methamphetamine (0.93; 95% CI: 0.88, 0.98, per 10 use-years), cocaine (0.93; 95% CI: 0.89, 0.96, per 10 use-years) and cumulative medical visits (0.99; 95% CI: 0.98, 0.99, per 10 visit-years), each showed small negative associations with CD4+/CD8+ ratios. Among HIV2 men, cumulative medical visits (0.996; 95% CI: 0.993, 0.999), cumulative number of male sexual partners (0.999; 95% CI: 0.998, 0.9998, per 10 partner-years) and cigarette pack-years (1.10; 95% CI: 1.02, 1.18, per 10 pack-years) were associated with CD4+/CD8+ ratios over the same period. ART adherence is associated with a positive immune function independent of stimulant use, underscoring the influence of ART on immune health for HIV{thorn} men who engage in stimulant use.
KW - Adherence
KW - Antiretroviral therapy
KW - CD4+/CD8+ ratio
KW - Cocaine
KW - HIV
KW - Men
KW - Methamphetamine
KW - Multicenter AIDS Cohort Study
UR - http://www.scopus.com/inward/record.url?scp=84865814357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865814357&partnerID=8YFLogxK
U2 - 10.1258/ijsa.2012.011322
DO - 10.1258/ijsa.2012.011322
M3 - Article
C2 - 22930295
AN - SCOPUS:84865814357
VL - 23
SP - 576
EP - 580
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
SN - 0956-4624
IS - 8
ER -