Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

Shaozhong Wang, Jianwei Sun, Gang Yu, Xiaoyi Hu, Jun Liu, Yuefei Hu

Research output: Contribution to journalArticle

Abstract

An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.

Original languageEnglish (US)
Pages (from-to)1573-1574
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume2
Issue number11
DOIs
StatePublished - Jun 7 2004

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Chalcone
Nitriles
nitriles
Ketones
Amides
ketones
amides
Nitrogen
routes
Derivatives
nitrogen
preparation
rings

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones. / Wang, Shaozhong; Sun, Jianwei; Yu, Gang; Hu, Xiaoyi; Liu, Jun; Hu, Yuefei.

In: Organic and Biomolecular Chemistry, Vol. 2, No. 11, 07.06.2004, p. 1573-1574.

Research output: Contribution to journalArticle

Wang, Shaozhong ; Sun, Jianwei ; Yu, Gang ; Hu, Xiaoyi ; Liu, Jun ; Hu, Yuefei. / Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones. In: Organic and Biomolecular Chemistry. 2004 ; Vol. 2, No. 11. pp. 1573-1574.
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