Cul catalyzed N-arylation of amide as a key step for the preparation of 3-aryl β-carbolin-1-ones

Shaozhong Wang, Jianwei Sun, Gang Yu, Xiaoyi Hu, Jun O. Liu, Yuefei Hu

Research output: Contribution to journalReview articlepeer-review

Abstract

An expedient synthetic route for 3-aryl β-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the β-carbolin-1- ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.

Original languageEnglish (US)
Pages (from-to)1573-1574
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume2
Issue number11
DOIs
StatePublished - Jun 7 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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