CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members

Jonathan M. Peterson, Zhikui Wei, G. William Wong

Research output: Contribution to journalArticlepeer-review

Abstract

C1q/TNF family comprises over thirty secreted multimeric proteins that play diverse and important roles in immune, endocrine, skeletal, neuronal, reproductive, sensory, and vascular systems. Here we describe two novel human C1q/TNF family members, designated as CTRP8 and CTRP9B. Both genes are absent in the mouse genome. CTRP8 is expressed predominantly in lung and testis. In addition to forming homotrimers, CTRP8 also forms heteromeric complexes with C1q-related factor (CRF). CRF is a secreted multimeric protein that forms heteromeric complexes with CTRP1, CTRP9, and CTRP10. Although human CTRRP9A and CTRP9B share 98% amino acid identity, they are encoded by distinct genes and are biochemically distinct. While CTRP9A is robustly secreted as a multimeric protein, CTRP9B requires physical association with CTRP9A or adiponectin for its secretion. We propose here that combinatorial association between C1q/TNF family members is a possible mechanism to generate an expanded repertoire of functionally distinct ligands with altered function and/or receptor specificity.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume388
Issue number2
DOIs
StatePublished - Oct 16 2009

Keywords

  • Adipokine
  • C1q-related factor
  • C1q/TNF family
  • C1qTNF
  • CRF
  • CTRP9
  • Combinatorial association
  • Hetero-oligomer
  • Multimeric

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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