CT metrics of airway disease and emphysema in severe COPD

Woo Jin Kim, Edwin K. Silverman, Eric Hoffman, Gerard J. Criner, Zab Mosenifar, Frank C. Sciurba, Barry J. Make, Vincent Carey, Raúl San José Estépar, Alejandro Diaz, John J. Reilly, Fernando J. Martinez, George R. Washko, Alfred P. Fishman, Betsy Ann Bozzarello, Ameena Al-Amin, Marcia Katz, Carolyn Wheeler, Elaine Baker, Peter Barnard & 434 others Phil Cagle, James Carter, Sophia Chatziioannou, Karla Conejo-Gonzales, Kimberly Dubose, John Haddad, David Hicks, Neal Kleiman, Mary Milburn-Barnes, Chinh Nguyen, Michael Reardon, Joseph Reeves-Viets, Steven Sax, Amir Sharafkhaneh, Owen Wilson, Christine Young, Rafael Espada, Rose Butanda, Minnie Ellisor, Pamela Fox, Katherine Hale, Everett Hood, Amy Jahn, Satish Jhingran, Karen King, Charles Miller, Imran Nizami, Todd Officer, Jeannie Ricketts, Joe Rodarte, Robert Teague, Kedren Williams, John Reilly, David Sugarbaker, Carol Fanning, Simon Body, Sabine Duffy, Vladmir Formanek, Anne Fuhlbrigge, Philip Hartigan, Sarah Hooper, Andetta Hunsaker, Francine Jacobson, Marilyn Moy, Susan Peterson, Roger Russell, Diane Saunders, Scott Swanson, Rob McKenna, Zab Mohsenifar, Carol Geaga, Manmohan Biring, Susan Clark, Jennifer Cutler, Robert Frantz, Peter Julien, Michael Lewis, Jennifer Minkoff-Rau, Valentina Yegyan, Milton Joyner, Malcolm De-Camp, James Stoller, Yvonne Meli, John Apostolakis, Darryl Atwell, Jeffrey Chapman, Pierre DeVilliers, Raed Dweik, Erik Kraenzler, Rosemary Lann, Nancy Kurokawa, Scott Marlow, Kevin McCarthy, Priscilla McCreight, Atul Mehta, Moulay Meziane, Omar Minai, Mindi Steiger, Kenneth White, Janet Maurer, Terri Durr, Charles Hearn, Susan Lubell, Peter O'Donovan, Robert Schilz, Mark Ginsburg, Byron Thomashow, Patricia Jellen, John Austin, Matthew Bartels, Yahya Berkmen, Patricia Berkoski, Frances Brogan, Amy Chong, Glenda DeMercado, Angela DiMango, Sandy Do, Bessie Kachulis, Arfa Khan, Berend Mets, Mitchell O'Shea, Gregory Pearson, Leonard Rossoff, Steven Scharf, Maria Shiau, Paul Simonelli, Kim Stavrolakes, Donna Tsang, Denise Vilotijevic, Chun Yip, Mike Mantinaos, Kerri McKeon, Jacqueline Pfeffer, Neil MacIntyre, R. Duane Davis, John Howe, R. Edward Coleman, Rebecca Crouch, Dora Greene, Katherine Grichnik, David Harpole, Abby Krichman, Brian Lawlor, Holman McAdams, John Plankeel, Susan Rinaldo-Gallo, Sheila Shearer, Jeanne Smith, Mark Stafford-Smith, Victor Tapson, Mark Steele, Jennifer Norten, James Utz, Claude Deschamps, Kathy Mieras, Martin Abel, Mark Allen, Deb Andrist, Gregory Aughenbaugh, Sharon Bendel, Eric Edell, Marlene Edgar, Bonnie Edwards, Beth Elliot, James Garrett, Delmar Gillespie, Judd Gurney, Boleyn Hammel, Karen Hanson, Lori Hanson, Gordon Harms, June Hart, Thomas Hartman, Robert Hyatt, Eric Jensen, Nicole Jenson, Sanjay Kalra, Philip Karsell, Jennifer Lamb, David Midthun, Carl Mottram, Stephen Swensen, Anne Marie Sykes, Karen Taylor, Norman Torres, Rolf Hubmayr, Daniel Miller, Sara Bartling, Kris Bradt, Barry Make, Marvin Pomerantz, Mary Gilmartin, Joyce Canterbury, Martin Carlos, Phyllis Dibbern, Enrique Fernandez, Lisa Geyman, Connie Hudson, David Lynch, John Newell, Robert Quaife, Jennifer Propst, Cynthia Raymond, Jane Whalen-Price, Kathy Winner, Martin Zamora, Reuben Cherniack, Philip Diaz, Patrick Ross, Tina Bees, Jan Drake, Charles Emery, Mark Gerhardt, Mark King, David Rittinger, Mahasti Rittinger, Keith Naunheim, Robert Gerber, Joan Osterloh, Susan Borosh, Willard Chamberlain, Sally Frese, Alan Hibbit, Mary Ellen Kleinhenz, Gregg Ruppel, Cary Stolar, Janice Willey, Francisco Alvarez, Cesar Keller, Gerard Criner, Satoshi Furukawa, Anne Marie Kuzma, Roger Barnette, Neil Brister, Kevin Carney, Wissam Chatila, Francis Cordova, Gilbert D'Alonzo, Michael Keresztury, Karen Kirsch, Chul Kwak, Kathy Lautensack, Madelina Lorenzon, Ubaldo Martin, Peter Rising, Scott Schartel, John Travaline, Gwendolyn Vance, Phillip Boiselle, Gerald O'Brien, Andrew Ries, Robert Kaplan, Catherine Ramirez, David Frankville, Paul Friedman, James Harrell, Jeffery Johnson, David Kapelanski, David Kupferberg, Catherine Larsen, Trina Limberg, Michael Magliocca, Frank J. Papatheofanis, Dawn Sassi-Dambron, Melissa Weeks, Mark Krasna, Henry Eric Fessler, Iris Moskowitz, Timothy Gilbert, Jonathan B Orens, Dave Shade, Stanley Siegelman, Kenneth Silver, Clarence Weir, Charles White, Fernando Martinez, Mark Iannettoni, Catherine Meldrum, William Bria, Kelly Campbell, Paul Christensen, Kevin Flaherty, Steven Gay, Paramjit Gill, Paul Kazanjian, Ella Kazerooni, Vivian Knieper, Tammy Ojo, Lewis Poole, Leslie Quint, Paul Rysso, Thomas Sisson, Mercedes True, Brian Woodcock, Lori Zaremba, Larry Kaiser, John Hansen-Flaschen, Mary Louise Dempsey, Abass Alavi, Theresa Alcorn, Selim Arcasoy, Judith Aronchick, Stanley Aukberg, Bryan Benedict, Susan Craemer, Ron Daniele, Jeffrey Edelman, Warren Gefter, Laura Kotler-Klein, Robert Kotloff, David Lipson, Wallace Miller, Richard O'Connell, Staci Opelman, Harold Palevsky, William Russell, Heather Sheaffer, Rodney Simcox, Susanne Snedeker, Jennifer Stone-Wynne, Gregory Tino, Peter Wahl, James Walter, Patricia Ward, David Zisman, James Mendez, Angela Wurster, Frank Sciurba, James Luketich, Colleen Witt, Gerald Ayres, Michael Donahoe, Carl Fuhrman, Robert Hoffman, Joan Lacomis, Joan Sexton, William Slivka, Diane Strollo, Erin Sullivan, Tomeka Simon, Catherine Wrona, Gerene Bauldoff, Manuel Brown, Elisabeth George, Robert Keenan, Theodore Kopp, Laurie Silfies, Joshua Benditt, Douglas Wood, Margaret Snyder, Kymberley Anable, Nancy Battaglia, Louie Boitano, Andrew Bowdle, Leighton Chan, Cindy Chwalik, Bruce Culver, Thurman Gillespy, David Godwin, Jeanne Hoffman, Andra Ibrahim, Diane Lockhart, Stephen Marglin, Kenneth Martay, Patricia McDowell, Donald Oxorn, Liz Roessler, Michelle Toshima, Susan Golden, Lynn Bosco, Yen Pin Chiang, Carolyn Clancy, Harry Handelsman, Steven M. Berkowitz, Tanisha Carino, Joe Chin, JoAnna Baldwin, Karen McVearry, Anthony Norris, Sarah Shirey, Claudette Sikora, Steven Sheingold, Steven Piantadosi, James A Tonascia, Patricia Belt, Amanda Blackford, Karen Collins, Betty Collison, Ryan Colvin, John Dodge, Michele Donithan, Vera Edmonds, Gregory L. Foster, Julie Fuller, Judith Harle, Rosetta Jackson, Shing Lee, Charlene Levine, Hope Livingston, Jill Meinert, Jennifer Meyers, Deborah Nowakowski, Kapreena Owens, Shangqian Qi, Michael Smith, Brett Simon, Paul Smith, Alice L Sternberg, Mark L Van Natta, Laura Wilson, Robert A Wise, Robert M. Kaplan, J. Sanford Schwartz, Marianne C. Fahs, A. Mark Fendrick, Alan J. Moskowitz, Dev Pathak, Scott Ramsey, A. Laurie Shroyer, Judith Wagner, Roger Yusen, Ruth Etzioni, Sean Sullivan, Thomas Schroeder, Karma Kreizenbeck, Kristin Berry, Nadia Howlader, Janice Cook-Granroth, Angela Delsing, Junfeng Guo, Geoffrey McLennan, Brian Mullan, Chris Piker, Joseph Reinhardt, Blake Wood, Jered Sieren, William Stanford, John A. Waldhausen, Gordon Bernard, David DeMets, Mark Ferguson, Eddie Hoover, Robert Levine, Donald Mahler, A. John McSweeny, Jeanine Wiener-Kronish, Dale Williams, Magdy Younes, Charles Soltoff, Gail Weinmann, Joanne Deshler, Dean Follmann, James Kiley, Margaret Wu

Research output: Contribution to journalArticle

Abstract

Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalChest
Volume136
Issue number2
DOIs
StatePublished - Aug 1 2009

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Emphysema
Chronic Obstructive Pulmonary Disease
Phenotype
Lung
Dyspnea
Linear Models
Multivariate Analysis
Regression Analysis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, W. J., Silverman, E. K., Hoffman, E., Criner, G. J., Mosenifar, Z., Sciurba, F. C., ... Wu, M. (2009). CT metrics of airway disease and emphysema in severe COPD. Chest, 136(2), 396-404. https://doi.org/10.1378/chest.08-2858

CT metrics of airway disease and emphysema in severe COPD. / Kim, Woo Jin; Silverman, Edwin K.; Hoffman, Eric; Criner, Gerard J.; Mosenifar, Zab; Sciurba, Frank C.; Make, Barry J.; Carey, Vincent; San José Estépar, Raúl; Diaz, Alejandro; Reilly, John J.; Martinez, Fernando J.; Washko, George R.; Fishman, Alfred P.; Bozzarello, Betsy Ann; Al-Amin, Ameena; Katz, Marcia; Wheeler, Carolyn; Baker, Elaine; Barnard, Peter; Cagle, Phil; Carter, James; Chatziioannou, Sophia; Conejo-Gonzales, Karla; Dubose, Kimberly; Haddad, John; Hicks, David; Kleiman, Neal; Milburn-Barnes, Mary; Nguyen, Chinh; Reardon, Michael; Reeves-Viets, Joseph; Sax, Steven; Sharafkhaneh, Amir; Wilson, Owen; Young, Christine; Espada, Rafael; Butanda, Rose; Ellisor, Minnie; Fox, Pamela; Hale, Katherine; Hood, Everett; Jahn, Amy; Jhingran, Satish; King, Karen; Miller, Charles; Nizami, Imran; Officer, Todd; Ricketts, Jeannie; Rodarte, Joe; Teague, Robert; Williams, Kedren; Reilly, John; Sugarbaker, David; Fanning, Carol; Body, Simon; Duffy, Sabine; Formanek, Vladmir; Fuhlbrigge, Anne; Hartigan, Philip; Hooper, Sarah; Hunsaker, Andetta; Jacobson, Francine; Moy, Marilyn; Peterson, Susan; Russell, Roger; Saunders, Diane; Swanson, Scott; McKenna, Rob; Mohsenifar, Zab; Geaga, Carol; Biring, Manmohan; Clark, Susan; Cutler, Jennifer; Frantz, Robert; Julien, Peter; Lewis, Michael; Minkoff-Rau, Jennifer; Yegyan, Valentina; Joyner, Milton; De-Camp, Malcolm; Stoller, James; Meli, Yvonne; Apostolakis, John; Atwell, Darryl; Chapman, Jeffrey; DeVilliers, Pierre; Dweik, Raed; Kraenzler, Erik; Lann, Rosemary; Kurokawa, Nancy; Marlow, Scott; McCarthy, Kevin; McCreight, Priscilla; Mehta, Atul; Meziane, Moulay; Minai, Omar; Steiger, Mindi; White, Kenneth; Maurer, Janet; Durr, Terri; Hearn, Charles; Lubell, Susan; O'Donovan, Peter; Schilz, Robert; Ginsburg, Mark; Thomashow, Byron; Jellen, Patricia; Austin, John; Bartels, Matthew; Berkmen, Yahya; Berkoski, Patricia; Brogan, Frances; Chong, Amy; DeMercado, Glenda; DiMango, Angela; Do, Sandy; Kachulis, Bessie; Khan, Arfa; Mets, Berend; O'Shea, Mitchell; Pearson, Gregory; Rossoff, Leonard; Scharf, Steven; Shiau, Maria; Simonelli, Paul; Stavrolakes, Kim; Tsang, Donna; Vilotijevic, Denise; Yip, Chun; Mantinaos, Mike; McKeon, Kerri; Pfeffer, Jacqueline; MacIntyre, Neil; Davis, R. Duane; Howe, John; Coleman, R. Edward; Crouch, Rebecca; Greene, Dora; Grichnik, Katherine; Harpole, David; Krichman, Abby; Lawlor, Brian; McAdams, Holman; Plankeel, John; Rinaldo-Gallo, Susan; Shearer, Sheila; Smith, Jeanne; Stafford-Smith, Mark; Tapson, Victor; Steele, Mark; Norten, Jennifer; Utz, James; Deschamps, Claude; Mieras, Kathy; Abel, Martin; Allen, Mark; Andrist, Deb; Aughenbaugh, Gregory; Bendel, Sharon; Edell, Eric; Edgar, Marlene; Edwards, Bonnie; Elliot, Beth; Garrett, James; Gillespie, Delmar; Gurney, Judd; Hammel, Boleyn; Hanson, Karen; Hanson, Lori; Harms, Gordon; Hart, June; Hartman, Thomas; Hyatt, Robert; Jensen, Eric; Jenson, Nicole; Kalra, Sanjay; Karsell, Philip; Lamb, Jennifer; Midthun, David; Mottram, Carl; Swensen, Stephen; Sykes, Anne Marie; Taylor, Karen; Torres, Norman; Hubmayr, Rolf; Miller, Daniel; Bartling, Sara; Bradt, Kris; Make, Barry; Pomerantz, Marvin; Gilmartin, Mary; Canterbury, Joyce; Carlos, Martin; Dibbern, Phyllis; Fernandez, Enrique; Geyman, Lisa; Hudson, Connie; Lynch, David; Newell, John; Quaife, Robert; Propst, Jennifer; Raymond, Cynthia; Whalen-Price, Jane; Winner, Kathy; Zamora, Martin; Cherniack, Reuben; Diaz, Philip; Ross, Patrick; Bees, Tina; Drake, Jan; Emery, Charles; Gerhardt, Mark; King, Mark; Rittinger, David; Rittinger, Mahasti; Naunheim, Keith; Gerber, Robert; Osterloh, Joan; Borosh, Susan; Chamberlain, Willard; Frese, Sally; Hibbit, Alan; Kleinhenz, Mary Ellen; Ruppel, Gregg; Stolar, Cary; Willey, Janice; Alvarez, Francisco; Keller, Cesar; Criner, Gerard; Furukawa, Satoshi; Kuzma, Anne Marie; Barnette, Roger; Brister, Neil; Carney, Kevin; Chatila, Wissam; Cordova, Francis; D'Alonzo, Gilbert; Keresztury, Michael; Kirsch, Karen; Kwak, Chul; Lautensack, Kathy; Lorenzon, Madelina; Martin, Ubaldo; Rising, Peter; Schartel, Scott; Travaline, John; Vance, Gwendolyn; Boiselle, Phillip; O'Brien, Gerald; Ries, Andrew; Kaplan, Robert; Ramirez, Catherine; Frankville, David; Friedman, Paul; Harrell, James; Johnson, Jeffery; Kapelanski, David; Kupferberg, David; Larsen, Catherine; Limberg, Trina; Magliocca, Michael; Papatheofanis, Frank J.; Sassi-Dambron, Dawn; Weeks, Melissa; Krasna, Mark; Fessler, Henry Eric; Moskowitz, Iris; Gilbert, Timothy; Orens, Jonathan B; Shade, Dave; Siegelman, Stanley; Silver, Kenneth; Weir, Clarence; White, Charles; Martinez, Fernando; Iannettoni, Mark; Meldrum, Catherine; Bria, William; Campbell, Kelly; Christensen, Paul; Flaherty, Kevin; Gay, Steven; Gill, Paramjit; Kazanjian, Paul; Kazerooni, Ella; Knieper, Vivian; Ojo, Tammy; Poole, Lewis; Quint, Leslie; Rysso, Paul; Sisson, Thomas; True, Mercedes; Woodcock, Brian; Zaremba, Lori; Kaiser, Larry; Hansen-Flaschen, John; Dempsey, Mary Louise; Alavi, Abass; Alcorn, Theresa; Arcasoy, Selim; Aronchick, Judith; Aukberg, Stanley; Benedict, Bryan; Craemer, Susan; Daniele, Ron; Edelman, Jeffrey; Gefter, Warren; Kotler-Klein, Laura; Kotloff, Robert; Lipson, David; Miller, Wallace; O'Connell, Richard; Opelman, Staci; Palevsky, Harold; Russell, William; Sheaffer, Heather; Simcox, Rodney; Snedeker, Susanne; Stone-Wynne, Jennifer; Tino, Gregory; Wahl, Peter; Walter, James; Ward, Patricia; Zisman, David; Mendez, James; Wurster, Angela; Sciurba, Frank; Luketich, James; Witt, Colleen; Ayres, Gerald; Donahoe, Michael; Fuhrman, Carl; Hoffman, Robert; Lacomis, Joan; Sexton, Joan; Slivka, William; Strollo, Diane; Sullivan, Erin; Simon, Tomeka; Wrona, Catherine; Bauldoff, Gerene; Brown, Manuel; George, Elisabeth; Keenan, Robert; Kopp, Theodore; Silfies, Laurie; Benditt, Joshua; Wood, Douglas; Snyder, Margaret; Anable, Kymberley; Battaglia, Nancy; Boitano, Louie; Bowdle, Andrew; Chan, Leighton; Chwalik, Cindy; Culver, Bruce; Gillespy, Thurman; Godwin, David; Hoffman, Jeanne; Ibrahim, Andra; Lockhart, Diane; Marglin, Stephen; Martay, Kenneth; McDowell, Patricia; Oxorn, Donald; Roessler, Liz; Toshima, Michelle; Golden, Susan; Bosco, Lynn; Chiang, Yen Pin; Clancy, Carolyn; Handelsman, Harry; Berkowitz, Steven M.; Carino, Tanisha; Chin, Joe; Baldwin, JoAnna; McVearry, Karen; Norris, Anthony; Shirey, Sarah; Sikora, Claudette; Sheingold, Steven; Piantadosi, Steven; Tonascia, James A; Belt, Patricia; Blackford, Amanda; Collins, Karen; Collison, Betty; Colvin, Ryan; Dodge, John; Donithan, Michele; Edmonds, Vera; Foster, Gregory L.; Fuller, Julie; Harle, Judith; Jackson, Rosetta; Lee, Shing; Levine, Charlene; Livingston, Hope; Meinert, Jill; Meyers, Jennifer; Nowakowski, Deborah; Owens, Kapreena; Qi, Shangqian; Smith, Michael; Simon, Brett; Smith, Paul; Sternberg, Alice L; Van Natta, Mark L; Wilson, Laura; Wise, Robert A; Kaplan, Robert M.; Schwartz, J. Sanford; Fahs, Marianne C.; Fendrick, A. Mark; Moskowitz, Alan J.; Pathak, Dev; Ramsey, Scott; Shroyer, A. Laurie; Wagner, Judith; Yusen, Roger; Etzioni, Ruth; Sullivan, Sean; Schroeder, Thomas; Kreizenbeck, Karma; Berry, Kristin; Howlader, Nadia; Cook-Granroth, Janice; Delsing, Angela; Guo, Junfeng; McLennan, Geoffrey; Mullan, Brian; Piker, Chris; Reinhardt, Joseph; Wood, Blake; Sieren, Jered; Stanford, William; Waldhausen, John A.; Bernard, Gordon; DeMets, David; Ferguson, Mark; Hoover, Eddie; Levine, Robert; Mahler, Donald; McSweeny, A. John; Wiener-Kronish, Jeanine; Williams, Dale; Younes, Magdy; Soltoff, Charles; Weinmann, Gail; Deshler, Joanne; Follmann, Dean; Kiley, James; Wu, Margaret.

In: Chest, Vol. 136, No. 2, 01.08.2009, p. 396-404.

Research output: Contribution to journalArticle

Kim, WJ, Silverman, EK, Hoffman, E, Criner, GJ, Mosenifar, Z, Sciurba, FC, Make, BJ, Carey, V, San José Estépar, R, Diaz, A, Reilly, JJ, Martinez, FJ, Washko, GR, Fishman, AP, Bozzarello, BA, Al-Amin, A, Katz, M, Wheeler, C, Baker, E, Barnard, P, Cagle, P, Carter, J, Chatziioannou, S, Conejo-Gonzales, K, Dubose, K, Haddad, J, Hicks, D, Kleiman, N, Milburn-Barnes, M, Nguyen, C, Reardon, M, Reeves-Viets, J, Sax, S, Sharafkhaneh, A, Wilson, O, Young, C, Espada, R, Butanda, R, Ellisor, M, Fox, P, Hale, K, Hood, E, Jahn, A, Jhingran, S, King, K, Miller, C, Nizami, I, Officer, T, Ricketts, J, Rodarte, J, Teague, R, Williams, K, Reilly, J, Sugarbaker, D, Fanning, C, Body, S, Duffy, S, Formanek, V, Fuhlbrigge, A, Hartigan, P, Hooper, S, Hunsaker, A, Jacobson, F, Moy, M, Peterson, S, Russell, R, Saunders, D, Swanson, S, McKenna, R, Mohsenifar, Z, Geaga, C, Biring, M, Clark, S, Cutler, J, Frantz, R, Julien, P, Lewis, M, Minkoff-Rau, J, Yegyan, V, Joyner, M, De-Camp, M, Stoller, J, Meli, Y, Apostolakis, J, Atwell, D, Chapman, J, DeVilliers, P, Dweik, R, Kraenzler, E, Lann, R, Kurokawa, N, Marlow, S, McCarthy, K, McCreight, P, Mehta, A, Meziane, M, Minai, O, Steiger, M, White, K, Maurer, J, Durr, T, Hearn, C, Lubell, S, O'Donovan, P, Schilz, R, Ginsburg, M, Thomashow, B, Jellen, P, Austin, J, Bartels, M, Berkmen, Y, Berkoski, P, Brogan, F, Chong, A, DeMercado, G, DiMango, A, Do, S, Kachulis, B, Khan, A, Mets, B, O'Shea, M, Pearson, G, Rossoff, L, Scharf, S, Shiau, M, Simonelli, P, Stavrolakes, K, Tsang, D, Vilotijevic, D, Yip, C, Mantinaos, M, McKeon, K, Pfeffer, J, MacIntyre, N, Davis, RD, Howe, J, Coleman, RE, Crouch, R, Greene, D, Grichnik, K, Harpole, D, Krichman, A, Lawlor, B, McAdams, H, Plankeel, J, Rinaldo-Gallo, S, Shearer, S, Smith, J, Stafford-Smith, M, Tapson, V, Steele, M, Norten, J, Utz, J, Deschamps, C, Mieras, K, Abel, M, Allen, M, Andrist, D, Aughenbaugh, G, Bendel, S, Edell, E, Edgar, M, Edwards, B, Elliot, B, Garrett, J, Gillespie, D, Gurney, J, Hammel, B, Hanson, K, Hanson, L, Harms, G, Hart, J, Hartman, T, Hyatt, R, Jensen, E, Jenson, N, Kalra, S, Karsell, P, Lamb, J, Midthun, D, Mottram, C, Swensen, S, Sykes, AM, Taylor, K, Torres, N, Hubmayr, R, Miller, D, Bartling, S, Bradt, K, Make, B, Pomerantz, M, Gilmartin, M, Canterbury, J, Carlos, M, Dibbern, P, Fernandez, E, Geyman, L, Hudson, C, Lynch, D, Newell, J, Quaife, R, Propst, J, Raymond, C, Whalen-Price, J, Winner, K, Zamora, M, Cherniack, R, Diaz, P, Ross, P, Bees, T, Drake, J, Emery, C, Gerhardt, M, King, M, Rittinger, D, Rittinger, M, Naunheim, K, Gerber, R, Osterloh, J, Borosh, S, Chamberlain, W, Frese, S, Hibbit, A, Kleinhenz, ME, Ruppel, G, Stolar, C, Willey, J, Alvarez, F, Keller, C, Criner, G, Furukawa, S, Kuzma, AM, Barnette, R, Brister, N, Carney, K, Chatila, W, Cordova, F, D'Alonzo, G, Keresztury, M, Kirsch, K, Kwak, C, Lautensack, K, Lorenzon, M, Martin, U, Rising, P, Schartel, S, Travaline, J, Vance, G, Boiselle, P, O'Brien, G, Ries, A, Kaplan, R, Ramirez, C, Frankville, D, Friedman, P, Harrell, J, Johnson, J, Kapelanski, D, Kupferberg, D, Larsen, C, Limberg, T, Magliocca, M, Papatheofanis, FJ, Sassi-Dambron, D, Weeks, M, Krasna, M, Fessler, HE, Moskowitz, I, Gilbert, T, Orens, JB, Shade, D, Siegelman, S, Silver, K, Weir, C, White, C, Martinez, F, Iannettoni, M, Meldrum, C, Bria, W, Campbell, K, Christensen, P, Flaherty, K, Gay, S, Gill, P, Kazanjian, P, Kazerooni, E, Knieper, V, Ojo, T, Poole, L, Quint, L, Rysso, P, Sisson, T, True, M, Woodcock, B, Zaremba, L, Kaiser, L, Hansen-Flaschen, J, Dempsey, ML, Alavi, A, Alcorn, T, Arcasoy, S, Aronchick, J, Aukberg, S, Benedict, B, Craemer, S, Daniele, R, Edelman, J, Gefter, W, Kotler-Klein, L, Kotloff, R, Lipson, D, Miller, W, O'Connell, R, Opelman, S, Palevsky, H, Russell, W, Sheaffer, H, Simcox, R, Snedeker, S, Stone-Wynne, J, Tino, G, Wahl, P, Walter, J, Ward, P, Zisman, D, Mendez, J, Wurster, A, Sciurba, F, Luketich, J, Witt, C, Ayres, G, Donahoe, M, Fuhrman, C, Hoffman, R, Lacomis, J, Sexton, J, Slivka, W, Strollo, D, Sullivan, E, Simon, T, Wrona, C, Bauldoff, G, Brown, M, George, E, Keenan, R, Kopp, T, Silfies, L, Benditt, J, Wood, D, Snyder, M, Anable, K, Battaglia, N, Boitano, L, Bowdle, A, Chan, L, Chwalik, C, Culver, B, Gillespy, T, Godwin, D, Hoffman, J, Ibrahim, A, Lockhart, D, Marglin, S, Martay, K, McDowell, P, Oxorn, D, Roessler, L, Toshima, M, Golden, S, Bosco, L, Chiang, YP, Clancy, C, Handelsman, H, Berkowitz, SM, Carino, T, Chin, J, Baldwin, J, McVearry, K, Norris, A, Shirey, S, Sikora, C, Sheingold, S, Piantadosi, S, Tonascia, JA, Belt, P, Blackford, A, Collins, K, Collison, B, Colvin, R, Dodge, J, Donithan, M, Edmonds, V, Foster, GL, Fuller, J, Harle, J, Jackson, R, Lee, S, Levine, C, Livingston, H, Meinert, J, Meyers, J, Nowakowski, D, Owens, K, Qi, S, Smith, M, Simon, B, Smith, P, Sternberg, AL, Van Natta, ML, Wilson, L, Wise, RA, Kaplan, RM, Schwartz, JS, Fahs, MC, Fendrick, AM, Moskowitz, AJ, Pathak, D, Ramsey, S, Shroyer, AL, Wagner, J, Yusen, R, Etzioni, R, Sullivan, S, Schroeder, T, Kreizenbeck, K, Berry, K, Howlader, N, Cook-Granroth, J, Delsing, A, Guo, J, McLennan, G, Mullan, B, Piker, C, Reinhardt, J, Wood, B, Sieren, J, Stanford, W, Waldhausen, JA, Bernard, G, DeMets, D, Ferguson, M, Hoover, E, Levine, R, Mahler, D, McSweeny, AJ, Wiener-Kronish, J, Williams, D, Younes, M, Soltoff, C, Weinmann, G, Deshler, J, Follmann, D, Kiley, J & Wu, M 2009, 'CT metrics of airway disease and emphysema in severe COPD', Chest, vol. 136, no. 2, pp. 396-404. https://doi.org/10.1378/chest.08-2858
Kim WJ, Silverman EK, Hoffman E, Criner GJ, Mosenifar Z, Sciurba FC et al. CT metrics of airway disease and emphysema in severe COPD. Chest. 2009 Aug 1;136(2):396-404. https://doi.org/10.1378/chest.08-2858
Kim, Woo Jin ; Silverman, Edwin K. ; Hoffman, Eric ; Criner, Gerard J. ; Mosenifar, Zab ; Sciurba, Frank C. ; Make, Barry J. ; Carey, Vincent ; San José Estépar, Raúl ; Diaz, Alejandro ; Reilly, John J. ; Martinez, Fernando J. ; Washko, George R. ; Fishman, Alfred P. ; Bozzarello, Betsy Ann ; Al-Amin, Ameena ; Katz, Marcia ; Wheeler, Carolyn ; Baker, Elaine ; Barnard, Peter ; Cagle, Phil ; Carter, James ; Chatziioannou, Sophia ; Conejo-Gonzales, Karla ; Dubose, Kimberly ; Haddad, John ; Hicks, David ; Kleiman, Neal ; Milburn-Barnes, Mary ; Nguyen, Chinh ; Reardon, Michael ; Reeves-Viets, Joseph ; Sax, Steven ; Sharafkhaneh, Amir ; Wilson, Owen ; Young, Christine ; Espada, Rafael ; Butanda, Rose ; Ellisor, Minnie ; Fox, Pamela ; Hale, Katherine ; Hood, Everett ; Jahn, Amy ; Jhingran, Satish ; King, Karen ; Miller, Charles ; Nizami, Imran ; Officer, Todd ; Ricketts, Jeannie ; Rodarte, Joe ; Teague, Robert ; Williams, Kedren ; Reilly, John ; Sugarbaker, David ; Fanning, Carol ; Body, Simon ; Duffy, Sabine ; Formanek, Vladmir ; Fuhlbrigge, Anne ; Hartigan, Philip ; Hooper, Sarah ; Hunsaker, Andetta ; Jacobson, Francine ; Moy, Marilyn ; Peterson, Susan ; Russell, Roger ; Saunders, Diane ; Swanson, Scott ; McKenna, Rob ; Mohsenifar, Zab ; Geaga, Carol ; Biring, Manmohan ; Clark, Susan ; Cutler, Jennifer ; Frantz, Robert ; Julien, Peter ; Lewis, Michael ; Minkoff-Rau, Jennifer ; Yegyan, Valentina ; Joyner, Milton ; De-Camp, Malcolm ; Stoller, James ; Meli, Yvonne ; Apostolakis, John ; Atwell, Darryl ; Chapman, Jeffrey ; DeVilliers, Pierre ; Dweik, Raed ; Kraenzler, Erik ; Lann, Rosemary ; Kurokawa, Nancy ; Marlow, Scott ; McCarthy, Kevin ; McCreight, Priscilla ; Mehta, Atul ; Meziane, Moulay ; Minai, Omar ; Steiger, Mindi ; White, Kenneth ; Maurer, Janet ; Durr, Terri ; Hearn, Charles ; Lubell, Susan ; O'Donovan, Peter ; Schilz, Robert ; Ginsburg, Mark ; Thomashow, Byron ; Jellen, Patricia ; Austin, John ; Bartels, Matthew ; Berkmen, Yahya ; Berkoski, Patricia ; Brogan, Frances ; Chong, Amy ; DeMercado, Glenda ; DiMango, Angela ; Do, Sandy ; Kachulis, Bessie ; Khan, Arfa ; Mets, Berend ; O'Shea, Mitchell ; Pearson, Gregory ; Rossoff, Leonard ; Scharf, Steven ; Shiau, Maria ; Simonelli, Paul ; Stavrolakes, Kim ; Tsang, Donna ; Vilotijevic, Denise ; Yip, Chun ; Mantinaos, Mike ; McKeon, Kerri ; Pfeffer, Jacqueline ; MacIntyre, Neil ; Davis, R. Duane ; Howe, John ; Coleman, R. Edward ; Crouch, Rebecca ; Greene, Dora ; Grichnik, Katherine ; Harpole, David ; Krichman, Abby ; Lawlor, Brian ; McAdams, Holman ; Plankeel, John ; Rinaldo-Gallo, Susan ; Shearer, Sheila ; Smith, Jeanne ; Stafford-Smith, Mark ; Tapson, Victor ; Steele, Mark ; Norten, Jennifer ; Utz, James ; Deschamps, Claude ; Mieras, Kathy ; Abel, Martin ; Allen, Mark ; Andrist, Deb ; Aughenbaugh, Gregory ; Bendel, Sharon ; Edell, Eric ; Edgar, Marlene ; Edwards, Bonnie ; Elliot, Beth ; Garrett, James ; Gillespie, Delmar ; Gurney, Judd ; Hammel, Boleyn ; Hanson, Karen ; Hanson, Lori ; Harms, Gordon ; Hart, June ; Hartman, Thomas ; Hyatt, Robert ; Jensen, Eric ; Jenson, Nicole ; Kalra, Sanjay ; Karsell, Philip ; Lamb, Jennifer ; Midthun, David ; Mottram, Carl ; Swensen, Stephen ; Sykes, Anne Marie ; Taylor, Karen ; Torres, Norman ; Hubmayr, Rolf ; Miller, Daniel ; Bartling, Sara ; Bradt, Kris ; Make, Barry ; Pomerantz, Marvin ; Gilmartin, Mary ; Canterbury, Joyce ; Carlos, Martin ; Dibbern, Phyllis ; Fernandez, Enrique ; Geyman, Lisa ; Hudson, Connie ; Lynch, David ; Newell, John ; Quaife, Robert ; Propst, Jennifer ; Raymond, Cynthia ; Whalen-Price, Jane ; Winner, Kathy ; Zamora, Martin ; Cherniack, Reuben ; Diaz, Philip ; Ross, Patrick ; Bees, Tina ; Drake, Jan ; Emery, Charles ; Gerhardt, Mark ; King, Mark ; Rittinger, David ; Rittinger, Mahasti ; Naunheim, Keith ; Gerber, Robert ; Osterloh, Joan ; Borosh, Susan ; Chamberlain, Willard ; Frese, Sally ; Hibbit, Alan ; Kleinhenz, Mary Ellen ; Ruppel, Gregg ; Stolar, Cary ; Willey, Janice ; Alvarez, Francisco ; Keller, Cesar ; Criner, Gerard ; Furukawa, Satoshi ; Kuzma, Anne Marie ; Barnette, Roger ; Brister, Neil ; Carney, Kevin ; Chatila, Wissam ; Cordova, Francis ; D'Alonzo, Gilbert ; Keresztury, Michael ; Kirsch, Karen ; Kwak, Chul ; Lautensack, Kathy ; Lorenzon, Madelina ; Martin, Ubaldo ; Rising, Peter ; Schartel, Scott ; Travaline, John ; Vance, Gwendolyn ; Boiselle, Phillip ; O'Brien, Gerald ; Ries, Andrew ; Kaplan, Robert ; Ramirez, Catherine ; Frankville, David ; Friedman, Paul ; Harrell, James ; Johnson, Jeffery ; Kapelanski, David ; Kupferberg, David ; Larsen, Catherine ; Limberg, Trina ; Magliocca, Michael ; Papatheofanis, Frank J. ; Sassi-Dambron, Dawn ; Weeks, Melissa ; Krasna, Mark ; Fessler, Henry Eric ; Moskowitz, Iris ; Gilbert, Timothy ; Orens, Jonathan B ; Shade, Dave ; Siegelman, Stanley ; Silver, Kenneth ; Weir, Clarence ; White, Charles ; Martinez, Fernando ; Iannettoni, Mark ; Meldrum, Catherine ; Bria, William ; Campbell, Kelly ; Christensen, Paul ; Flaherty, Kevin ; Gay, Steven ; Gill, Paramjit ; Kazanjian, Paul ; Kazerooni, Ella ; Knieper, Vivian ; Ojo, Tammy ; Poole, Lewis ; Quint, Leslie ; Rysso, Paul ; Sisson, Thomas ; True, Mercedes ; Woodcock, Brian ; Zaremba, Lori ; Kaiser, Larry ; Hansen-Flaschen, John ; Dempsey, Mary Louise ; Alavi, Abass ; Alcorn, Theresa ; Arcasoy, Selim ; Aronchick, Judith ; Aukberg, Stanley ; Benedict, Bryan ; Craemer, Susan ; Daniele, Ron ; Edelman, Jeffrey ; Gefter, Warren ; Kotler-Klein, Laura ; Kotloff, Robert ; Lipson, David ; Miller, Wallace ; O'Connell, Richard ; Opelman, Staci ; Palevsky, Harold ; Russell, William ; Sheaffer, Heather ; Simcox, Rodney ; Snedeker, Susanne ; Stone-Wynne, Jennifer ; Tino, Gregory ; Wahl, Peter ; Walter, James ; Ward, Patricia ; Zisman, David ; Mendez, James ; Wurster, Angela ; Sciurba, Frank ; Luketich, James ; Witt, Colleen ; Ayres, Gerald ; Donahoe, Michael ; Fuhrman, Carl ; Hoffman, Robert ; Lacomis, Joan ; Sexton, Joan ; Slivka, William ; Strollo, Diane ; Sullivan, Erin ; Simon, Tomeka ; Wrona, Catherine ; Bauldoff, Gerene ; Brown, Manuel ; George, Elisabeth ; Keenan, Robert ; Kopp, Theodore ; Silfies, Laurie ; Benditt, Joshua ; Wood, Douglas ; Snyder, Margaret ; Anable, Kymberley ; Battaglia, Nancy ; Boitano, Louie ; Bowdle, Andrew ; Chan, Leighton ; Chwalik, Cindy ; Culver, Bruce ; Gillespy, Thurman ; Godwin, David ; Hoffman, Jeanne ; Ibrahim, Andra ; Lockhart, Diane ; Marglin, Stephen ; Martay, Kenneth ; McDowell, Patricia ; Oxorn, Donald ; Roessler, Liz ; Toshima, Michelle ; Golden, Susan ; Bosco, Lynn ; Chiang, Yen Pin ; Clancy, Carolyn ; Handelsman, Harry ; Berkowitz, Steven M. ; Carino, Tanisha ; Chin, Joe ; Baldwin, JoAnna ; McVearry, Karen ; Norris, Anthony ; Shirey, Sarah ; Sikora, Claudette ; Sheingold, Steven ; Piantadosi, Steven ; Tonascia, James A ; Belt, Patricia ; Blackford, Amanda ; Collins, Karen ; Collison, Betty ; Colvin, Ryan ; Dodge, John ; Donithan, Michele ; Edmonds, Vera ; Foster, Gregory L. ; Fuller, Julie ; Harle, Judith ; Jackson, Rosetta ; Lee, Shing ; Levine, Charlene ; Livingston, Hope ; Meinert, Jill ; Meyers, Jennifer ; Nowakowski, Deborah ; Owens, Kapreena ; Qi, Shangqian ; Smith, Michael ; Simon, Brett ; Smith, Paul ; Sternberg, Alice L ; Van Natta, Mark L ; Wilson, Laura ; Wise, Robert A ; Kaplan, Robert M. ; Schwartz, J. Sanford ; Fahs, Marianne C. ; Fendrick, A. Mark ; Moskowitz, Alan J. ; Pathak, Dev ; Ramsey, Scott ; Shroyer, A. Laurie ; Wagner, Judith ; Yusen, Roger ; Etzioni, Ruth ; Sullivan, Sean ; Schroeder, Thomas ; Kreizenbeck, Karma ; Berry, Kristin ; Howlader, Nadia ; Cook-Granroth, Janice ; Delsing, Angela ; Guo, Junfeng ; McLennan, Geoffrey ; Mullan, Brian ; Piker, Chris ; Reinhardt, Joseph ; Wood, Blake ; Sieren, Jered ; Stanford, William ; Waldhausen, John A. ; Bernard, Gordon ; DeMets, David ; Ferguson, Mark ; Hoover, Eddie ; Levine, Robert ; Mahler, Donald ; McSweeny, A. John ; Wiener-Kronish, Jeanine ; Williams, Dale ; Younes, Magdy ; Soltoff, Charles ; Weinmann, Gail ; Deshler, Joanne ; Follmann, Dean ; Kiley, James ; Wu, Margaret. / CT metrics of airway disease and emphysema in severe COPD. In: Chest. 2009 ; Vol. 136, No. 2. pp. 396-404.
@article{926976f7136448b69f175d84d9bf6e6a,
title = "CT metrics of airway disease and emphysema in severe COPD",
abstract = "Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units ({\%}LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between {\%}LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1{\%} predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and {\%}LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1{\%} predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.",
author = "Kim, {Woo Jin} and Silverman, {Edwin K.} and Eric Hoffman and Criner, {Gerard J.} and Zab Mosenifar and Sciurba, {Frank C.} and Make, {Barry J.} and Vincent Carey and {San Jos{\'e} Est{\'e}par}, Ra{\'u}l and Alejandro Diaz and Reilly, {John J.} and Martinez, {Fernando J.} and Washko, {George R.} and Fishman, {Alfred P.} and Bozzarello, {Betsy Ann} and Ameena Al-Amin and Marcia Katz and Carolyn Wheeler and Elaine Baker and Peter Barnard and Phil Cagle and James Carter and Sophia Chatziioannou and Karla Conejo-Gonzales and Kimberly Dubose and John Haddad and David Hicks and Neal Kleiman and Mary Milburn-Barnes and Chinh Nguyen and Michael Reardon and Joseph Reeves-Viets and Steven Sax and Amir Sharafkhaneh and Owen Wilson and Christine Young and Rafael Espada and Rose Butanda and Minnie Ellisor and Pamela Fox and Katherine Hale and Everett Hood and Amy Jahn and Satish Jhingran and Karen King and Charles Miller and Imran Nizami and Todd Officer and Jeannie Ricketts and Joe Rodarte and Robert Teague and Kedren Williams and John Reilly and David Sugarbaker and Carol Fanning and Simon Body and Sabine Duffy and Vladmir Formanek and Anne Fuhlbrigge and Philip Hartigan and Sarah Hooper and Andetta Hunsaker and Francine Jacobson and Marilyn Moy and Susan Peterson and Roger Russell and Diane Saunders and Scott Swanson and Rob McKenna and Zab Mohsenifar and Carol Geaga and Manmohan Biring and Susan Clark and Jennifer Cutler and Robert Frantz and Peter Julien and Michael Lewis and Jennifer Minkoff-Rau and Valentina Yegyan and Milton Joyner and Malcolm De-Camp and James Stoller and Yvonne Meli and John Apostolakis and Darryl Atwell and Jeffrey Chapman and Pierre DeVilliers and Raed Dweik and Erik Kraenzler and Rosemary Lann and Nancy Kurokawa and Scott Marlow and Kevin McCarthy and Priscilla McCreight and Atul Mehta and Moulay Meziane and Omar Minai and Mindi Steiger and Kenneth White and Janet Maurer and Terri Durr and Charles Hearn and Susan Lubell and Peter O'Donovan and Robert Schilz and Mark Ginsburg and Byron Thomashow and Patricia Jellen and John Austin and Matthew Bartels and Yahya Berkmen and Patricia Berkoski and Frances Brogan and Amy Chong and Glenda DeMercado and Angela DiMango and Sandy Do and Bessie Kachulis and Arfa Khan and Berend Mets and Mitchell O'Shea and Gregory Pearson and Leonard Rossoff and Steven Scharf and Maria Shiau and Paul Simonelli and Kim Stavrolakes and Donna Tsang and Denise Vilotijevic and Chun Yip and Mike Mantinaos and Kerri McKeon and Jacqueline Pfeffer and Neil MacIntyre and Davis, {R. Duane} and John Howe and Coleman, {R. Edward} and Rebecca Crouch and Dora Greene and Katherine Grichnik and David Harpole and Abby Krichman and Brian Lawlor and Holman McAdams and John Plankeel and Susan Rinaldo-Gallo and Sheila Shearer and Jeanne Smith and Mark Stafford-Smith and Victor Tapson and Mark Steele and Jennifer Norten and James Utz and Claude Deschamps and Kathy Mieras and Martin Abel and Mark Allen and Deb Andrist and Gregory Aughenbaugh and Sharon Bendel and Eric Edell and Marlene Edgar and Bonnie Edwards and Beth Elliot and James Garrett and Delmar Gillespie and Judd Gurney and Boleyn Hammel and Karen Hanson and Lori Hanson and Gordon Harms and June Hart and Thomas Hartman and Robert Hyatt and Eric Jensen and Nicole Jenson and Sanjay Kalra and Philip Karsell and Jennifer Lamb and David Midthun and Carl Mottram and Stephen Swensen and Sykes, {Anne Marie} and Karen Taylor and Norman Torres and Rolf Hubmayr and Daniel Miller and Sara Bartling and Kris Bradt and Barry Make and Marvin Pomerantz and Mary Gilmartin and Joyce Canterbury and Martin Carlos and Phyllis Dibbern and Enrique Fernandez and Lisa Geyman and Connie Hudson and David Lynch and John Newell and Robert Quaife and Jennifer Propst and Cynthia Raymond and Jane Whalen-Price and Kathy Winner and Martin Zamora and Reuben Cherniack and Philip Diaz and Patrick Ross and Tina Bees and Jan Drake and Charles Emery and Mark Gerhardt and Mark King and David Rittinger and Mahasti Rittinger and Keith Naunheim and Robert Gerber and Joan Osterloh and Susan Borosh and Willard Chamberlain and Sally Frese and Alan Hibbit and Kleinhenz, {Mary Ellen} and Gregg Ruppel and Cary Stolar and Janice Willey and Francisco Alvarez and Cesar Keller and Gerard Criner and Satoshi Furukawa and Kuzma, {Anne Marie} and Roger Barnette and Neil Brister and Kevin Carney and Wissam Chatila and Francis Cordova and Gilbert D'Alonzo and Michael Keresztury and Karen Kirsch and Chul Kwak and Kathy Lautensack and Madelina Lorenzon and Ubaldo Martin and Peter Rising and Scott Schartel and John Travaline and Gwendolyn Vance and Phillip Boiselle and Gerald O'Brien and Andrew Ries and Robert Kaplan and Catherine Ramirez and David Frankville and Paul Friedman and James Harrell and Jeffery Johnson and David Kapelanski and David Kupferberg and Catherine Larsen and Trina Limberg and Michael Magliocca and Papatheofanis, {Frank J.} and Dawn Sassi-Dambron and Melissa Weeks and Mark Krasna and Fessler, {Henry Eric} and Iris Moskowitz and Timothy Gilbert and Orens, {Jonathan B} and Dave Shade and Stanley Siegelman and Kenneth Silver and Clarence Weir and Charles White and Fernando Martinez and Mark Iannettoni and Catherine Meldrum and William Bria and Kelly Campbell and Paul Christensen and Kevin Flaherty and Steven Gay and Paramjit Gill and Paul Kazanjian and Ella Kazerooni and Vivian Knieper and Tammy Ojo and Lewis Poole and Leslie Quint and Paul Rysso and Thomas Sisson and Mercedes True and Brian Woodcock and Lori Zaremba and Larry Kaiser and John Hansen-Flaschen and Dempsey, {Mary Louise} and Abass Alavi and Theresa Alcorn and Selim Arcasoy and Judith Aronchick and Stanley Aukberg and Bryan Benedict and Susan Craemer and Ron Daniele and Jeffrey Edelman and Warren Gefter and Laura Kotler-Klein and Robert Kotloff and David Lipson and Wallace Miller and Richard O'Connell and Staci Opelman and Harold Palevsky and William Russell and Heather Sheaffer and Rodney Simcox and Susanne Snedeker and Jennifer Stone-Wynne and Gregory Tino and Peter Wahl and James Walter and Patricia Ward and David Zisman and James Mendez and Angela Wurster and Frank Sciurba and James Luketich and Colleen Witt and Gerald Ayres and Michael Donahoe and Carl Fuhrman and Robert Hoffman and Joan Lacomis and Joan Sexton and William Slivka and Diane Strollo and Erin Sullivan and Tomeka Simon and Catherine Wrona and Gerene Bauldoff and Manuel Brown and Elisabeth George and Robert Keenan and Theodore Kopp and Laurie Silfies and Joshua Benditt and Douglas Wood and Margaret Snyder and Kymberley Anable and Nancy Battaglia and Louie Boitano and Andrew Bowdle and Leighton Chan and Cindy Chwalik and Bruce Culver and Thurman Gillespy and David Godwin and Jeanne Hoffman and Andra Ibrahim and Diane Lockhart and Stephen Marglin and Kenneth Martay and Patricia McDowell and Donald Oxorn and Liz Roessler and Michelle Toshima and Susan Golden and Lynn Bosco and Chiang, {Yen Pin} and Carolyn Clancy and Harry Handelsman and Berkowitz, {Steven M.} and Tanisha Carino and Joe Chin and JoAnna Baldwin and Karen McVearry and Anthony Norris and Sarah Shirey and Claudette Sikora and Steven Sheingold and Steven Piantadosi and Tonascia, {James A} and Patricia Belt and Amanda Blackford and Karen Collins and Betty Collison and Ryan Colvin and John Dodge and Michele Donithan and Vera Edmonds and Foster, {Gregory L.} and Julie Fuller and Judith Harle and Rosetta Jackson and Shing Lee and Charlene Levine and Hope Livingston and Jill Meinert and Jennifer Meyers and Deborah Nowakowski and Kapreena Owens and Shangqian Qi and Michael Smith and Brett Simon and Paul Smith and Sternberg, {Alice L} and {Van Natta}, {Mark L} and Laura Wilson and Wise, {Robert A} and Kaplan, {Robert M.} and Schwartz, {J. Sanford} and Fahs, {Marianne C.} and Fendrick, {A. Mark} and Moskowitz, {Alan J.} and Dev Pathak and Scott Ramsey and Shroyer, {A. Laurie} and Judith Wagner and Roger Yusen and Ruth Etzioni and Sean Sullivan and Thomas Schroeder and Karma Kreizenbeck and Kristin Berry and Nadia Howlader and Janice Cook-Granroth and Angela Delsing and Junfeng Guo and Geoffrey McLennan and Brian Mullan and Chris Piker and Joseph Reinhardt and Blake Wood and Jered Sieren and William Stanford and Waldhausen, {John A.} and Gordon Bernard and David DeMets and Mark Ferguson and Eddie Hoover and Robert Levine and Donald Mahler and McSweeny, {A. John} and Jeanine Wiener-Kronish and Dale Williams and Magdy Younes and Charles Soltoff and Gail Weinmann and Joanne Deshler and Dean Follmann and James Kiley and Margaret Wu",
year = "2009",
month = "8",
day = "1",
doi = "10.1378/chest.08-2858",
language = "English (US)",
volume = "136",
pages = "396--404",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "2",

}

TY - JOUR

T1 - CT metrics of airway disease and emphysema in severe COPD

AU - Kim, Woo Jin

AU - Silverman, Edwin K.

AU - Hoffman, Eric

AU - Criner, Gerard J.

AU - Mosenifar, Zab

AU - Sciurba, Frank C.

AU - Make, Barry J.

AU - Carey, Vincent

AU - San José Estépar, Raúl

AU - Diaz, Alejandro

AU - Reilly, John J.

AU - Martinez, Fernando J.

AU - Washko, George R.

AU - Fishman, Alfred P.

AU - Bozzarello, Betsy Ann

AU - Al-Amin, Ameena

AU - Katz, Marcia

AU - Wheeler, Carolyn

AU - Baker, Elaine

AU - Barnard, Peter

AU - Cagle, Phil

AU - Carter, James

AU - Chatziioannou, Sophia

AU - Conejo-Gonzales, Karla

AU - Dubose, Kimberly

AU - Haddad, John

AU - Hicks, David

AU - Kleiman, Neal

AU - Milburn-Barnes, Mary

AU - Nguyen, Chinh

AU - Reardon, Michael

AU - Reeves-Viets, Joseph

AU - Sax, Steven

AU - Sharafkhaneh, Amir

AU - Wilson, Owen

AU - Young, Christine

AU - Espada, Rafael

AU - Butanda, Rose

AU - Ellisor, Minnie

AU - Fox, Pamela

AU - Hale, Katherine

AU - Hood, Everett

AU - Jahn, Amy

AU - Jhingran, Satish

AU - King, Karen

AU - Miller, Charles

AU - Nizami, Imran

AU - Officer, Todd

AU - Ricketts, Jeannie

AU - Rodarte, Joe

AU - Teague, Robert

AU - Williams, Kedren

AU - Reilly, John

AU - Sugarbaker, David

AU - Fanning, Carol

AU - Body, Simon

AU - Duffy, Sabine

AU - Formanek, Vladmir

AU - Fuhlbrigge, Anne

AU - Hartigan, Philip

AU - Hooper, Sarah

AU - Hunsaker, Andetta

AU - Jacobson, Francine

AU - Moy, Marilyn

AU - Peterson, Susan

AU - Russell, Roger

AU - Saunders, Diane

AU - Swanson, Scott

AU - McKenna, Rob

AU - Mohsenifar, Zab

AU - Geaga, Carol

AU - Biring, Manmohan

AU - Clark, Susan

AU - Cutler, Jennifer

AU - Frantz, Robert

AU - Julien, Peter

AU - Lewis, Michael

AU - Minkoff-Rau, Jennifer

AU - Yegyan, Valentina

AU - Joyner, Milton

AU - De-Camp, Malcolm

AU - Stoller, James

AU - Meli, Yvonne

AU - Apostolakis, John

AU - Atwell, Darryl

AU - Chapman, Jeffrey

AU - DeVilliers, Pierre

AU - Dweik, Raed

AU - Kraenzler, Erik

AU - Lann, Rosemary

AU - Kurokawa, Nancy

AU - Marlow, Scott

AU - McCarthy, Kevin

AU - McCreight, Priscilla

AU - Mehta, Atul

AU - Meziane, Moulay

AU - Minai, Omar

AU - Steiger, Mindi

AU - White, Kenneth

AU - Maurer, Janet

AU - Durr, Terri

AU - Hearn, Charles

AU - Lubell, Susan

AU - O'Donovan, Peter

AU - Schilz, Robert

AU - Ginsburg, Mark

AU - Thomashow, Byron

AU - Jellen, Patricia

AU - Austin, John

AU - Bartels, Matthew

AU - Berkmen, Yahya

AU - Berkoski, Patricia

AU - Brogan, Frances

AU - Chong, Amy

AU - DeMercado, Glenda

AU - DiMango, Angela

AU - Do, Sandy

AU - Kachulis, Bessie

AU - Khan, Arfa

AU - Mets, Berend

AU - O'Shea, Mitchell

AU - Pearson, Gregory

AU - Rossoff, Leonard

AU - Scharf, Steven

AU - Shiau, Maria

AU - Simonelli, Paul

AU - Stavrolakes, Kim

AU - Tsang, Donna

AU - Vilotijevic, Denise

AU - Yip, Chun

AU - Mantinaos, Mike

AU - McKeon, Kerri

AU - Pfeffer, Jacqueline

AU - MacIntyre, Neil

AU - Davis, R. Duane

AU - Howe, John

AU - Coleman, R. Edward

AU - Crouch, Rebecca

AU - Greene, Dora

AU - Grichnik, Katherine

AU - Harpole, David

AU - Krichman, Abby

AU - Lawlor, Brian

AU - McAdams, Holman

AU - Plankeel, John

AU - Rinaldo-Gallo, Susan

AU - Shearer, Sheila

AU - Smith, Jeanne

AU - Stafford-Smith, Mark

AU - Tapson, Victor

AU - Steele, Mark

AU - Norten, Jennifer

AU - Utz, James

AU - Deschamps, Claude

AU - Mieras, Kathy

AU - Abel, Martin

AU - Allen, Mark

AU - Andrist, Deb

AU - Aughenbaugh, Gregory

AU - Bendel, Sharon

AU - Edell, Eric

AU - Edgar, Marlene

AU - Edwards, Bonnie

AU - Elliot, Beth

AU - Garrett, James

AU - Gillespie, Delmar

AU - Gurney, Judd

AU - Hammel, Boleyn

AU - Hanson, Karen

AU - Hanson, Lori

AU - Harms, Gordon

AU - Hart, June

AU - Hartman, Thomas

AU - Hyatt, Robert

AU - Jensen, Eric

AU - Jenson, Nicole

AU - Kalra, Sanjay

AU - Karsell, Philip

AU - Lamb, Jennifer

AU - Midthun, David

AU - Mottram, Carl

AU - Swensen, Stephen

AU - Sykes, Anne Marie

AU - Taylor, Karen

AU - Torres, Norman

AU - Hubmayr, Rolf

AU - Miller, Daniel

AU - Bartling, Sara

AU - Bradt, Kris

AU - Make, Barry

AU - Pomerantz, Marvin

AU - Gilmartin, Mary

AU - Canterbury, Joyce

AU - Carlos, Martin

AU - Dibbern, Phyllis

AU - Fernandez, Enrique

AU - Geyman, Lisa

AU - Hudson, Connie

AU - Lynch, David

AU - Newell, John

AU - Quaife, Robert

AU - Propst, Jennifer

AU - Raymond, Cynthia

AU - Whalen-Price, Jane

AU - Winner, Kathy

AU - Zamora, Martin

AU - Cherniack, Reuben

AU - Diaz, Philip

AU - Ross, Patrick

AU - Bees, Tina

AU - Drake, Jan

AU - Emery, Charles

AU - Gerhardt, Mark

AU - King, Mark

AU - Rittinger, David

AU - Rittinger, Mahasti

AU - Naunheim, Keith

AU - Gerber, Robert

AU - Osterloh, Joan

AU - Borosh, Susan

AU - Chamberlain, Willard

AU - Frese, Sally

AU - Hibbit, Alan

AU - Kleinhenz, Mary Ellen

AU - Ruppel, Gregg

AU - Stolar, Cary

AU - Willey, Janice

AU - Alvarez, Francisco

AU - Keller, Cesar

AU - Criner, Gerard

AU - Furukawa, Satoshi

AU - Kuzma, Anne Marie

AU - Barnette, Roger

AU - Brister, Neil

AU - Carney, Kevin

AU - Chatila, Wissam

AU - Cordova, Francis

AU - D'Alonzo, Gilbert

AU - Keresztury, Michael

AU - Kirsch, Karen

AU - Kwak, Chul

AU - Lautensack, Kathy

AU - Lorenzon, Madelina

AU - Martin, Ubaldo

AU - Rising, Peter

AU - Schartel, Scott

AU - Travaline, John

AU - Vance, Gwendolyn

AU - Boiselle, Phillip

AU - O'Brien, Gerald

AU - Ries, Andrew

AU - Kaplan, Robert

AU - Ramirez, Catherine

AU - Frankville, David

AU - Friedman, Paul

AU - Harrell, James

AU - Johnson, Jeffery

AU - Kapelanski, David

AU - Kupferberg, David

AU - Larsen, Catherine

AU - Limberg, Trina

AU - Magliocca, Michael

AU - Papatheofanis, Frank J.

AU - Sassi-Dambron, Dawn

AU - Weeks, Melissa

AU - Krasna, Mark

AU - Fessler, Henry Eric

AU - Moskowitz, Iris

AU - Gilbert, Timothy

AU - Orens, Jonathan B

AU - Shade, Dave

AU - Siegelman, Stanley

AU - Silver, Kenneth

AU - Weir, Clarence

AU - White, Charles

AU - Martinez, Fernando

AU - Iannettoni, Mark

AU - Meldrum, Catherine

AU - Bria, William

AU - Campbell, Kelly

AU - Christensen, Paul

AU - Flaherty, Kevin

AU - Gay, Steven

AU - Gill, Paramjit

AU - Kazanjian, Paul

AU - Kazerooni, Ella

AU - Knieper, Vivian

AU - Ojo, Tammy

AU - Poole, Lewis

AU - Quint, Leslie

AU - Rysso, Paul

AU - Sisson, Thomas

AU - True, Mercedes

AU - Woodcock, Brian

AU - Zaremba, Lori

AU - Kaiser, Larry

AU - Hansen-Flaschen, John

AU - Dempsey, Mary Louise

AU - Alavi, Abass

AU - Alcorn, Theresa

AU - Arcasoy, Selim

AU - Aronchick, Judith

AU - Aukberg, Stanley

AU - Benedict, Bryan

AU - Craemer, Susan

AU - Daniele, Ron

AU - Edelman, Jeffrey

AU - Gefter, Warren

AU - Kotler-Klein, Laura

AU - Kotloff, Robert

AU - Lipson, David

AU - Miller, Wallace

AU - O'Connell, Richard

AU - Opelman, Staci

AU - Palevsky, Harold

AU - Russell, William

AU - Sheaffer, Heather

AU - Simcox, Rodney

AU - Snedeker, Susanne

AU - Stone-Wynne, Jennifer

AU - Tino, Gregory

AU - Wahl, Peter

AU - Walter, James

AU - Ward, Patricia

AU - Zisman, David

AU - Mendez, James

AU - Wurster, Angela

AU - Sciurba, Frank

AU - Luketich, James

AU - Witt, Colleen

AU - Ayres, Gerald

AU - Donahoe, Michael

AU - Fuhrman, Carl

AU - Hoffman, Robert

AU - Lacomis, Joan

AU - Sexton, Joan

AU - Slivka, William

AU - Strollo, Diane

AU - Sullivan, Erin

AU - Simon, Tomeka

AU - Wrona, Catherine

AU - Bauldoff, Gerene

AU - Brown, Manuel

AU - George, Elisabeth

AU - Keenan, Robert

AU - Kopp, Theodore

AU - Silfies, Laurie

AU - Benditt, Joshua

AU - Wood, Douglas

AU - Snyder, Margaret

AU - Anable, Kymberley

AU - Battaglia, Nancy

AU - Boitano, Louie

AU - Bowdle, Andrew

AU - Chan, Leighton

AU - Chwalik, Cindy

AU - Culver, Bruce

AU - Gillespy, Thurman

AU - Godwin, David

AU - Hoffman, Jeanne

AU - Ibrahim, Andra

AU - Lockhart, Diane

AU - Marglin, Stephen

AU - Martay, Kenneth

AU - McDowell, Patricia

AU - Oxorn, Donald

AU - Roessler, Liz

AU - Toshima, Michelle

AU - Golden, Susan

AU - Bosco, Lynn

AU - Chiang, Yen Pin

AU - Clancy, Carolyn

AU - Handelsman, Harry

AU - Berkowitz, Steven M.

AU - Carino, Tanisha

AU - Chin, Joe

AU - Baldwin, JoAnna

AU - McVearry, Karen

AU - Norris, Anthony

AU - Shirey, Sarah

AU - Sikora, Claudette

AU - Sheingold, Steven

AU - Piantadosi, Steven

AU - Tonascia, James A

AU - Belt, Patricia

AU - Blackford, Amanda

AU - Collins, Karen

AU - Collison, Betty

AU - Colvin, Ryan

AU - Dodge, John

AU - Donithan, Michele

AU - Edmonds, Vera

AU - Foster, Gregory L.

AU - Fuller, Julie

AU - Harle, Judith

AU - Jackson, Rosetta

AU - Lee, Shing

AU - Levine, Charlene

AU - Livingston, Hope

AU - Meinert, Jill

AU - Meyers, Jennifer

AU - Nowakowski, Deborah

AU - Owens, Kapreena

AU - Qi, Shangqian

AU - Smith, Michael

AU - Simon, Brett

AU - Smith, Paul

AU - Sternberg, Alice L

AU - Van Natta, Mark L

AU - Wilson, Laura

AU - Wise, Robert A

AU - Kaplan, Robert M.

AU - Schwartz, J. Sanford

AU - Fahs, Marianne C.

AU - Fendrick, A. Mark

AU - Moskowitz, Alan J.

AU - Pathak, Dev

AU - Ramsey, Scott

AU - Shroyer, A. Laurie

AU - Wagner, Judith

AU - Yusen, Roger

AU - Etzioni, Ruth

AU - Sullivan, Sean

AU - Schroeder, Thomas

AU - Kreizenbeck, Karma

AU - Berry, Kristin

AU - Howlader, Nadia

AU - Cook-Granroth, Janice

AU - Delsing, Angela

AU - Guo, Junfeng

AU - McLennan, Geoffrey

AU - Mullan, Brian

AU - Piker, Chris

AU - Reinhardt, Joseph

AU - Wood, Blake

AU - Sieren, Jered

AU - Stanford, William

AU - Waldhausen, John A.

AU - Bernard, Gordon

AU - DeMets, David

AU - Ferguson, Mark

AU - Hoover, Eddie

AU - Levine, Robert

AU - Mahler, Donald

AU - McSweeny, A. John

AU - Wiener-Kronish, Jeanine

AU - Williams, Dale

AU - Younes, Magdy

AU - Soltoff, Charles

AU - Weinmann, Gail

AU - Deshler, Joanne

AU - Follmann, Dean

AU - Kiley, James

AU - Wu, Margaret

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

AB - Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

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U2 - 10.1378/chest.08-2858

DO - 10.1378/chest.08-2858

M3 - Article

VL - 136

SP - 396

EP - 404

JO - Chest

JF - Chest

SN - 0012-3692

IS - 2

ER -