TY - JOUR
T1 - CT imaging with ultra-high-resolution
T2 - Opportunities for cardiovascular imaging in clinical practice
AU - Schuijf, Joanne D.
AU - Lima, João A.C.
AU - Boedeker, Kirsten L.
AU - Takagi, Hidenobu
AU - Tanaka, Ryoichi
AU - Yoshioka, Kunihiro
AU - Arbab-Zadeh, Armin
N1 - Funding Information:
JDS and KLB are employees of Canon Medical Systems. JACL and AZ are supported by a research grant from Canon Medical Systems.
Publisher Copyright:
© 2022 The Authors
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Cardiovascular computed tomography (CT) angiography has become an established alternative to invasive catheter angiography. However, imaging artifacts due to partial volume effects with current systems hinder accurate evaluation of calcified or stented segments. Increased spatial resolution may allow to overcome these barriers to precise delineation of vascular disease. Recent developments in CT hardware and reconstruction have enabled CT angiography with ultra-high spatial resolution (UHRCT). In this review we aim to describe the methods to achieve greater spatial resolution in CT that are either in clinical or preclinical stage. In addition, we provide an overview of the available clinical evidence including diagnostic accuracy studies supporting improved vascular assessment with this technology. The benefits that can be gleaned from the initial experiences with UHRCT are promising. Using UHRCT, more patients may receive non-invasive characterization of coronary atherosclerosis by overcoming the limitations of current CT spatial resolution in visualizing and quantifying calcified, stented or small diameter segments. UHRCT may potentially impact existing management pathways as well as contribute to better understanding of the underlying pathophysiology of both macro- and microvascular disease.
AB - Cardiovascular computed tomography (CT) angiography has become an established alternative to invasive catheter angiography. However, imaging artifacts due to partial volume effects with current systems hinder accurate evaluation of calcified or stented segments. Increased spatial resolution may allow to overcome these barriers to precise delineation of vascular disease. Recent developments in CT hardware and reconstruction have enabled CT angiography with ultra-high spatial resolution (UHRCT). In this review we aim to describe the methods to achieve greater spatial resolution in CT that are either in clinical or preclinical stage. In addition, we provide an overview of the available clinical evidence including diagnostic accuracy studies supporting improved vascular assessment with this technology. The benefits that can be gleaned from the initial experiences with UHRCT are promising. Using UHRCT, more patients may receive non-invasive characterization of coronary atherosclerosis by overcoming the limitations of current CT spatial resolution in visualizing and quantifying calcified, stented or small diameter segments. UHRCT may potentially impact existing management pathways as well as contribute to better understanding of the underlying pathophysiology of both macro- and microvascular disease.
KW - Computed tomography
KW - Coronary artery disease
KW - Coronary computed tomography angiography
KW - Ultra-high resolution CT
KW - Vascular imaging
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U2 - 10.1016/j.jcct.2022.02.003
DO - 10.1016/j.jcct.2022.02.003
M3 - Review article
C2 - 35210183
AN - SCOPUS:85125793802
SN - 1934-5925
VL - 16
SP - 388
EP - 396
JO - Journal of cardiovascular computed tomography
JF - Journal of cardiovascular computed tomography
IS - 5
ER -