CT angiographic evaluation of genetic vascular disease: Role in detection, staging, and management of complex vascular pathologic conditions

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. Arterial dissection and aneurysm rupture are significant sources of morbidity and mortality in patients with connective tissue diseases. This article provides a detailed analysis of cardiovascular involvement in Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. CONCLUSION. Although these syndromes share some overlapping features, they have discriminating clinical and imaging features, and knowledge of these features enables the radiologist to aid the referring clinician in making the correct diagnosis.

Original languageEnglish (US)
Pages (from-to)1120-1129
Number of pages10
JournalAmerican Journal of Roentgenology
Volume202
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Loeys-Dietz Syndrome
Ehlers-Danlos Syndrome
Marfan Syndrome
Inborn Genetic Diseases
Connective Tissue Diseases
Vascular Diseases
Aneurysm
Blood Vessels
Dissection
Rupture
Morbidity
Mortality
Radiologists

Keywords

  • Aneurysm
  • CT angiography
  • Ehlers-Danlos syndrome
  • Loeys-Dietz syndrome
  • Marfan syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "CT angiographic evaluation of genetic vascular disease: Role in detection, staging, and management of complex vascular pathologic conditions",
abstract = "OBJECTIVE. Arterial dissection and aneurysm rupture are significant sources of morbidity and mortality in patients with connective tissue diseases. This article provides a detailed analysis of cardiovascular involvement in Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. CONCLUSION. Although these syndromes share some overlapping features, they have discriminating clinical and imaging features, and knowledge of these features enables the radiologist to aid the referring clinician in making the correct diagnosis.",
keywords = "Aneurysm, CT angiography, Ehlers-Danlos syndrome, Loeys-Dietz syndrome, Marfan syndrome",
author = "Chu, {Linda Chi Hang} and Pamela Johnson and Dietz, {Harry C} and Fishman, {Elliot K}",
year = "2014",
doi = "10.2214/AJR.13.11485",
language = "English (US)",
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T1 - CT angiographic evaluation of genetic vascular disease

T2 - Role in detection, staging, and management of complex vascular pathologic conditions

AU - Chu, Linda Chi Hang

AU - Johnson, Pamela

AU - Dietz, Harry C

AU - Fishman, Elliot K

PY - 2014

Y1 - 2014

N2 - OBJECTIVE. Arterial dissection and aneurysm rupture are significant sources of morbidity and mortality in patients with connective tissue diseases. This article provides a detailed analysis of cardiovascular involvement in Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. CONCLUSION. Although these syndromes share some overlapping features, they have discriminating clinical and imaging features, and knowledge of these features enables the radiologist to aid the referring clinician in making the correct diagnosis.

AB - OBJECTIVE. Arterial dissection and aneurysm rupture are significant sources of morbidity and mortality in patients with connective tissue diseases. This article provides a detailed analysis of cardiovascular involvement in Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. CONCLUSION. Although these syndromes share some overlapping features, they have discriminating clinical and imaging features, and knowledge of these features enables the radiologist to aid the referring clinician in making the correct diagnosis.

KW - Aneurysm

KW - CT angiography

KW - Ehlers-Danlos syndrome

KW - Loeys-Dietz syndrome

KW - Marfan syndrome

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