CSF soluble Fas correlates with the severity of HIV-associated dementia

A. Towfighi, R. L. Skolasky, C. St. Hillaire, K. Conant, Justin C. McArthur

Research output: Contribution to journalArticlepeer-review

Abstract

Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia (HIV-D). The authors investigated whether these markers correlated with dementia severity and course. sFas and sFasL were measured in 15 highly active antiretroviral therapy (HAART)-naïve HIV-D subjects, 30 HAART-naïve HIV+ controls, and 17 HIV- controls. HIV-D subjects had higher CSF sFas levels than controls. Subjects with moderate/severe dementia had higher CSF sFas levels than those with mild dementia. CSF sFas trended lower in those with progressive dementia.

Original languageEnglish (US)
Pages (from-to)654-656
Number of pages3
JournalNeurology
Volume62
Issue number4
DOIs
StatePublished - Feb 24 2004

ASJC Scopus subject areas

  • Clinical Neurology

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