Abstract
Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia (HIV-D). The authors investigated whether these markers correlated with dementia severity and course. sFas and sFasL were measured in 15 highly active antiretroviral therapy (HAART)-naïve HIV-D subjects, 30 HAART-naïve HIV+ controls, and 17 HIV- controls. HIV-D subjects had higher CSF sFas levels than controls. Subjects with moderate/severe dementia had higher CSF sFas levels than those with mild dementia. CSF sFas trended lower in those with progressive dementia.
Original language | English (US) |
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Pages (from-to) | 654-656 |
Number of pages | 3 |
Journal | Neurology |
Volume | 62 |
Issue number | 4 |
DOIs | |
State | Published - Feb 24 2004 |
ASJC Scopus subject areas
- Clinical Neurology