CSF HCO3- regulation in isosmotic conditions: The role of brain PCO2 and plasma HCO3-

E. E. Nattie; Lewis Romer

doi:10.1016/0034-5687(78)90068-3

CSF HCO₃^- regulation in isosmotic conditions: The role of brain P_CO₂ and plasma HCO₃^-

E. E. Nattie, Lewis Romer

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have studied in anesthetized cats the response of CSF HCO₃^- to (1) an increase in CSF P_CO₂, plasma HCO₃^- controlled at the normal value; (2) an increase in plasma HCO₃^-, CSF P_CO₂ controlled at the normal value; and (3) an increase in both CSF P_CO₂ and plasma HCO₃^-. Plasma HCO₃^- was controlled via HCO₃^-/Cl^- exchange without altering plasma Na concentration or osmolarity using the technique of peritoneal dialysis. The results suggest that CSF HCO₃^- regulation in these conditions is dependent on (1) a P_CO₂-dependent process in which HCO₃^- ions are formed in brain cells or choroid plexus and (2) an ionic movement of HCO₃^- from plasma to CSF dependent on an increase in plasma HCO₃^-. The first process is largely completed by 3 hours; the second takes 6 hours or more. An analysis of plasma and CSF HCO₃^-, Cl^- and unmeasured anions (UA), (Na⁺ + K⁺ -Cl^- -HCO₃^-), suggests that CSF HCO₃^- regulation may be complex involving ionic exchanges of three or more anions between brain extracellular fluid, plasma and brain cells.

Original language	English (US)
Pages (from-to)	177-198
Number of pages	22
Journal	Respiration Physiology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0034-5687(78)90068-3
State	Published - May 1978
Externally published	Yes

Keywords

Brain metabolism
Cerebrospinal fluid
Extracellular fluid
Ionic movements

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/0034-5687(78)90068-3

Cite this

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title = "CSF HCO3- regulation in isosmotic conditions: The role of brain PCO2 and plasma HCO3-",

abstract = "We have studied in anesthetized cats the response of CSF HCO3- to (1) an increase in CSF PCO2, plasma HCO3- controlled at the normal value; (2) an increase in plasma HCO3-, CSF PCO2 controlled at the normal value; and (3) an increase in both CSF PCO2 and plasma HCO3-. Plasma HCO3- was controlled via HCO3-/Cl- exchange without altering plasma Na concentration or osmolarity using the technique of peritoneal dialysis. The results suggest that CSF HCO3- regulation in these conditions is dependent on (1) a PCO2-dependent process in which HCO3- ions are formed in brain cells or choroid plexus and (2) an ionic movement of HCO3- from plasma to CSF dependent on an increase in plasma HCO3-. The first process is largely completed by 3 hours; the second takes 6 hours or more. An analysis of plasma and CSF HCO3-, Cl- and unmeasured anions (UA), (Na+ + K+ -Cl- -HCO3-), suggests that CSF HCO3- regulation may be complex involving ionic exchanges of three or more anions between brain extracellular fluid, plasma and brain cells.",

keywords = "Brain metabolism, Cerebrospinal fluid, Extracellular fluid, Ionic movements",

author = "Nattie, {E. E.} and Lewis Romer",

note = "Funding Information: l This investigation was supported in part by an allocation from Grant 5S07-RR-05392 from the Biomedical Research Support Branch, Division of Research Resources, NIH, by a Young Pulmonary Investigator Award, HL 18351, to Dr. Nattie from the Heart and Lung Institute, NIH, and by a Public Health Service Research Grant, HL 02888.",

year = "1978",

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doi = "10.1016/0034-5687(78)90068-3",

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T2 - The role of brain PCO2 and plasma HCO3-

AU - Nattie, E. E.

AU - Romer, Lewis

N1 - Funding Information: l This investigation was supported in part by an allocation from Grant 5S07-RR-05392 from the Biomedical Research Support Branch, Division of Research Resources, NIH, by a Young Pulmonary Investigator Award, HL 18351, to Dr. Nattie from the Heart and Lung Institute, NIH, and by a Public Health Service Research Grant, HL 02888.

PY - 1978/5

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N2 - We have studied in anesthetized cats the response of CSF HCO3- to (1) an increase in CSF PCO2, plasma HCO3- controlled at the normal value; (2) an increase in plasma HCO3-, CSF PCO2 controlled at the normal value; and (3) an increase in both CSF PCO2 and plasma HCO3-. Plasma HCO3- was controlled via HCO3-/Cl- exchange without altering plasma Na concentration or osmolarity using the technique of peritoneal dialysis. The results suggest that CSF HCO3- regulation in these conditions is dependent on (1) a PCO2-dependent process in which HCO3- ions are formed in brain cells or choroid plexus and (2) an ionic movement of HCO3- from plasma to CSF dependent on an increase in plasma HCO3-. The first process is largely completed by 3 hours; the second takes 6 hours or more. An analysis of plasma and CSF HCO3-, Cl- and unmeasured anions (UA), (Na+ + K+ -Cl- -HCO3-), suggests that CSF HCO3- regulation may be complex involving ionic exchanges of three or more anions between brain extracellular fluid, plasma and brain cells.

AB - We have studied in anesthetized cats the response of CSF HCO3- to (1) an increase in CSF PCO2, plasma HCO3- controlled at the normal value; (2) an increase in plasma HCO3-, CSF PCO2 controlled at the normal value; and (3) an increase in both CSF PCO2 and plasma HCO3-. Plasma HCO3- was controlled via HCO3-/Cl- exchange without altering plasma Na concentration or osmolarity using the technique of peritoneal dialysis. The results suggest that CSF HCO3- regulation in these conditions is dependent on (1) a PCO2-dependent process in which HCO3- ions are formed in brain cells or choroid plexus and (2) an ionic movement of HCO3- from plasma to CSF dependent on an increase in plasma HCO3-. The first process is largely completed by 3 hours; the second takes 6 hours or more. An analysis of plasma and CSF HCO3-, Cl- and unmeasured anions (UA), (Na+ + K+ -Cl- -HCO3-), suggests that CSF HCO3- regulation may be complex involving ionic exchanges of three or more anions between brain extracellular fluid, plasma and brain cells.

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KW - Ionic movements

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