Crystallographic and structural analysis studies of recombinant and chemically modified hemoglobins designed to aid development of artificial hemoglobin-based oxygen carriers

G. L. Gilliland, I. Pechik, X. Ji, C. Fronticelli, A. Razynska, H. Kwanse, E. Bucci

Research output: Contribution to journalConference articlepeer-review

Abstract

Crystallographic studies of liganded and unliganded forms of recombinant and chemically-crosslinked forms of human hemoglobin have been undertaken to assist in the development of artificial hemoglobin-based oxygen carriers. The crystal structure solution of each variant involves the collection of high resolution x-ray data using an electronic area detector followed by difference Fourier interpretation, alteration of the starting model followed by restrained least-squares refinement. These will then be described and compared with natural and other hemoglobins.

Original languageEnglish (US)
Pages (from-to)A101
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994
Externally publishedYes
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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