Crystallographic studies of liganded and unliganded forms of recombinant and chemically-crosslinked forms of human hemoglobin have been undertaken to assist in the development of artificial hemoglobin-based oxygen carriers. The crystal structure solution of each variant involves the collection of high resolution x-ray data using an electronic area detector followed by difference Fourier interpretation, alteration of the starting model followed by restrained least-squares refinement. These will then be described and compared with natural and other hemoglobins.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering