Crystallographic and structural analysis studies of recombinant and chemically modified hemoglobins designed to aid development of artificial hemoglobin-based oxygen carriers

G. L. Gilliland; I. Pechik; X. Ji; C. Fronticelli; A. Razynska; H. Kwanse; E. Bucci

Crystallographic and structural analysis studies of recombinant and chemically modified hemoglobins designed to aid development of artificial hemoglobin-based oxygen carriers

G. L. Gilliland, I. Pechik, X. Ji, C. Fronticelli, A. Razynska, H. Kwanse, E. Bucci

Research output: Contribution to journal › Conference article › peer-review

Abstract

Crystallographic studies of liganded and unliganded forms of recombinant and chemically-crosslinked forms of human hemoglobin have been undertaken to assist in the development of artificial hemoglobin-based oxygen carriers. The crystal structure solution of each variant involves the collection of high resolution x-ray data using an electronic area detector followed by difference Fourier interpretation, alteration of the starting model followed by restrained least-squares refinement. These will then be described and compared with natural and other hemoglobins.

Original language	English (US)
Pages (from-to)	A101
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1994
Externally published	Yes
Event	Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA Duration: Jul 24 1994 → Jul 27 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

Crystallographic and structural analysis studies of recombinant and chemically modified hemoglobins designed to aid development of artificial hemoglobin-based oxygen carriers. / Gilliland, G. L.; Pechik, I.; Ji, X. et al.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 11.1994, p. A101.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "Crystallographic studies of liganded and unliganded forms of recombinant and chemically-crosslinked forms of human hemoglobin have been undertaken to assist in the development of artificial hemoglobin-based oxygen carriers. The crystal structure solution of each variant involves the collection of high resolution x-ray data using an electronic area detector followed by difference Fourier interpretation, alteration of the starting model followed by restrained least-squares refinement. These will then be described and compared with natural and other hemoglobins.",

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AU - Gilliland, G. L.

AU - Pechik, I.

AU - Ji, X.

AU - Fronticelli, C.

AU - Razynska, A.

AU - Kwanse, H.

AU - Bucci, E.

PY - 1994/11

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AB - Crystallographic studies of liganded and unliganded forms of recombinant and chemically-crosslinked forms of human hemoglobin have been undertaken to assist in the development of artificial hemoglobin-based oxygen carriers. The crystal structure solution of each variant involves the collection of high resolution x-ray data using an electronic area detector followed by difference Fourier interpretation, alteration of the starting model followed by restrained least-squares refinement. These will then be described and compared with natural and other hemoglobins.

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M3 - Conference article

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VL - 22

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JO - Biomaterials, Artificial Cells, and Immobilization Biotechnology

JF - Biomaterials, Artificial Cells, and Immobilization Biotechnology

SN - 2169-1401

IS - 5

T2 - Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI)

Y2 - 24 July 1994 through 27 July 1994

ER -

Crystallographic and structural analysis studies of recombinant and chemically modified hemoglobins designed to aid development of artificial hemoglobin-based oxygen carriers

Abstract

ASJC Scopus subject areas

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