Crystal/cell interaction and nephrolithiasis

Saeed R. Khan

Research output: Contribution to journalArticle

Abstract

Crystals of calcium oxalate (CaOx), the major constituents of most urinary stones, are injurious to cells, create oxidative stress and evoke an inflammatory response. Renal injury results in cell damage. The damaged and dead cells are released into the urine and are capable of promoting crystal nucleation at much lower supersaturations. Damaged cell membranes also provide sites for crystal attachment and eventual retention within the kidneys. Renal epithelial damage may assist in movement of crystals from the intratubular to interstitial location and perhaps in the formation of apatitic Randall's plaques. Inflammatory response may be responsible for Randall's plaques ulceration to the renal papillary surface.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalArchivio Italiano di Urologia e Andrologia
Volume83
Issue number1
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Nephrolithiasis
Cell Communication
Kidney
Calcium Oxalate
Urinary Calculi
Oxidative Stress
Cell Membrane
Urine
Wounds and Injuries

Keywords

  • Calcium oxalate
  • Cells
  • Crystals
  • Inflammation
  • Urinary calculi

ASJC Scopus subject areas

  • Urology

Cite this

Crystal/cell interaction and nephrolithiasis. / Khan, Saeed R.

In: Archivio Italiano di Urologia e Andrologia, Vol. 83, No. 1, 03.2011, p. 1-5.

Research output: Contribution to journalArticle

@article{b46e21690f5048d68e1d09f87b190c6a,
title = "Crystal/cell interaction and nephrolithiasis",
abstract = "Crystals of calcium oxalate (CaOx), the major constituents of most urinary stones, are injurious to cells, create oxidative stress and evoke an inflammatory response. Renal injury results in cell damage. The damaged and dead cells are released into the urine and are capable of promoting crystal nucleation at much lower supersaturations. Damaged cell membranes also provide sites for crystal attachment and eventual retention within the kidneys. Renal epithelial damage may assist in movement of crystals from the intratubular to interstitial location and perhaps in the formation of apatitic Randall's plaques. Inflammatory response may be responsible for Randall's plaques ulceration to the renal papillary surface.",
keywords = "Calcium oxalate, Cells, Crystals, Inflammation, Urinary calculi",
author = "Khan, {Saeed R.}",
year = "2011",
month = "3",
language = "English (US)",
volume = "83",
pages = "1--5",
journal = "Archivio Italiano di Urologia Andrologia",
issn = "1124-3562",
publisher = "Edizioni Scripta Manent s.n.c.",
number = "1",

}

TY - JOUR

T1 - Crystal/cell interaction and nephrolithiasis

AU - Khan, Saeed R.

PY - 2011/3

Y1 - 2011/3

N2 - Crystals of calcium oxalate (CaOx), the major constituents of most urinary stones, are injurious to cells, create oxidative stress and evoke an inflammatory response. Renal injury results in cell damage. The damaged and dead cells are released into the urine and are capable of promoting crystal nucleation at much lower supersaturations. Damaged cell membranes also provide sites for crystal attachment and eventual retention within the kidneys. Renal epithelial damage may assist in movement of crystals from the intratubular to interstitial location and perhaps in the formation of apatitic Randall's plaques. Inflammatory response may be responsible for Randall's plaques ulceration to the renal papillary surface.

AB - Crystals of calcium oxalate (CaOx), the major constituents of most urinary stones, are injurious to cells, create oxidative stress and evoke an inflammatory response. Renal injury results in cell damage. The damaged and dead cells are released into the urine and are capable of promoting crystal nucleation at much lower supersaturations. Damaged cell membranes also provide sites for crystal attachment and eventual retention within the kidneys. Renal epithelial damage may assist in movement of crystals from the intratubular to interstitial location and perhaps in the formation of apatitic Randall's plaques. Inflammatory response may be responsible for Randall's plaques ulceration to the renal papillary surface.

KW - Calcium oxalate

KW - Cells

KW - Crystals

KW - Inflammation

KW - Urinary calculi

UR - http://www.scopus.com/inward/record.url?scp=79956099853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956099853&partnerID=8YFLogxK

M3 - Article

VL - 83

SP - 1

EP - 5

JO - Archivio Italiano di Urologia Andrologia

JF - Archivio Italiano di Urologia Andrologia

SN - 1124-3562

IS - 1

ER -