Crystal-matrix relationships in experimentally induced urinary calcium oxalate monohydrate crystals, an ultrastructural study

Saeed R. Khan, Raymond L. Hackett

Research output: Contribution to journalArticle

Abstract

Calcium oxalate monohydrate crystalluria was experimentally induced in male rats by administration of ethylene glycol. The crystalluria particles were separated by filtration and studied by scanning and transmission electron microscopy. They were associated with cellular degradation products. Organic material was present both on the surfaces of crystalluria particles as well as within them and was organized in radial striations and concentric laminations. It is proposed that crystal nuclei were formed by heterogeneous nucleation. These nuclei then adsorbed organic material and aggregated. The organic material polymerized resulting in the formation of a crystal-matrix unit which then grew and incorporated more organic material during the crystal growth.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalCalcified Tissue International
Volume41
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

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Calcium Oxalate
Scanning Transmission Electron Microscopy
Ethylene Glycol
Crystallization

Keywords

  • Calcium oxalate crystal nucleation
  • Crystal-matrix interface
  • Crystalluria
  • Urinary stone matrix
  • Urolithiasis

ASJC Scopus subject areas

  • Endocrinology
  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Crystal-matrix relationships in experimentally induced urinary calcium oxalate monohydrate crystals, an ultrastructural study. / Khan, Saeed R.; Hackett, Raymond L.

In: Calcified Tissue International, Vol. 41, No. 3, 09.1987, p. 157-163.

Research output: Contribution to journalArticle

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