TY - JOUR
T1 - Cryptosporidium species and subtypes and clinical manifestations in children, Peru
AU - Cama, Vitaliano A.
AU - Bern, Caryn
AU - Roberts, Jacqueline
AU - Cabrera, Lilia
AU - Sterling, Charles R.
AU - Ortega, Ynes
AU - Gilman, Robert H.
AU - Xiao, Lihua
PY - 2008/10
Y1 - 2008/10
N2 - To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
AB - To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
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U2 - 10.3201/eid1410.071273
DO - 10.3201/eid1410.071273
M3 - Article
C2 - 18826821
AN - SCOPUS:54249120352
SN - 1080-6040
VL - 14
SP - 1567
EP - 1574
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 10
ER -