Cryptosporidium parvum infection requires host cell actin polymerization

D. A. Elliott; D. J. Coleman; M. A. Lane; R. C. May; L. M. Machesky; D. P. Clark

doi:10.1128/IAI.69.9.5940-5942.2001

Cryptosporidium parvum infection requires host cell actin polymerization

D. A. Elliott, D. J. Coleman, M. A. Lane, R. C. May, L. M. Machesky, D. P. Clark

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Original language	English (US)
Pages (from-to)	5940-5942
Number of pages	3
Journal	Infection and immunity
Volume	69
Issue number	9
DOIs	https://doi.org/10.1128/IAI.69.9.5940-5942.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.69.9.5940-5942.2001

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abstract = "The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.",

author = "Elliott, {D. A.} and Coleman, {D. J.} and Lane, {M. A.} and May, {R. C.} and Machesky, {L. M.} and Clark, {D. P.}",

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AU - Elliott, D. A.

AU - Coleman, D. J.

AU - Lane, M. A.

AU - May, R. C.

AU - Machesky, L. M.

AU - Clark, D. P.

PY - 2001

Y1 - 2001

N2 - The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

AB - The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

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DO - 10.1128/IAI.69.9.5940-5942.2001

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JO - Infection and immunity

JF - Infection and immunity

IS - 9

ER -

Cryptosporidium parvum infection requires host cell actin polymerization

Abstract

ASJC Scopus subject areas

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