Cryptosporidium parvum infection requires host cell actin polymerization

D. A. Elliott, D. J. Coleman, M. A. Lane, R. C. May, L. M. Machesky, D. P. Clark

Research output: Contribution to journalArticle

Abstract

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Original languageEnglish (US)
Pages (from-to)5940-5942
Number of pages3
JournalInfection and Immunity
Volume69
Issue number9
DOIs
StatePublished - 2001

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Cryptosporidium parvum
Polymerization
Actins
Actin-Related Protein 2
Parasites
Infection
Wiskott-Aldrich Syndrome Protein
Parasitic Diseases
Cytoplasm

ASJC Scopus subject areas

  • Immunology

Cite this

Elliott, D. A., Coleman, D. J., Lane, M. A., May, R. C., Machesky, L. M., & Clark, D. P. (2001). Cryptosporidium parvum infection requires host cell actin polymerization. Infection and Immunity, 69(9), 5940-5942. https://doi.org/10.1128/IAI.69.9.5940-5942.2001

Cryptosporidium parvum infection requires host cell actin polymerization. / Elliott, D. A.; Coleman, D. J.; Lane, M. A.; May, R. C.; Machesky, L. M.; Clark, D. P.

In: Infection and Immunity, Vol. 69, No. 9, 2001, p. 5940-5942.

Research output: Contribution to journalArticle

Elliott, DA, Coleman, DJ, Lane, MA, May, RC, Machesky, LM & Clark, DP 2001, 'Cryptosporidium parvum infection requires host cell actin polymerization', Infection and Immunity, vol. 69, no. 9, pp. 5940-5942. https://doi.org/10.1128/IAI.69.9.5940-5942.2001
Elliott, D. A. ; Coleman, D. J. ; Lane, M. A. ; May, R. C. ; Machesky, L. M. ; Clark, D. P. / Cryptosporidium parvum infection requires host cell actin polymerization. In: Infection and Immunity. 2001 ; Vol. 69, No. 9. pp. 5940-5942.
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