Cryptosporidium parvum infection requires host cell actin polymerization

D. A. Elliott, D. J. Coleman, M. A. Lane, R. C. May, L. M. Machesky, D. P. Clark

Research output: Contribution to journalArticle

Abstract

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Original languageEnglish (US)
Pages (from-to)5940-5942
Number of pages3
JournalInfection and immunity
Volume69
Issue number9
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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  • Cite this

    Elliott, D. A., Coleman, D. J., Lane, M. A., May, R. C., Machesky, L. M., & Clark, D. P. (2001). Cryptosporidium parvum infection requires host cell actin polymerization. Infection and immunity, 69(9), 5940-5942. https://doi.org/10.1128/IAI.69.9.5940-5942.2001