Cryptococcus neoformans var. grubii: Separate varietal status for Cryptococcus neoformans serotype A isolates

Sarah P. Franzot, Ira F. Salkin, Arturo Casadevall

Research output: Contribution to journalArticle


Cryptococcus neoformans var. neoformans presently includes isolates which have been determined by the immunologic reactivity of their capsular polysaccharides to be serotype A and those which have been determined to be serotype D. However, recent analyses of the URA5 sequences and DNA fingerprinting patterns suggest significant genetic differences between the two serotypes. Therefore, we propose to recognize these genotypic distinctions, as well as previously reported phenotypic differences, by restricting C. neoformans var. neoformans to isolates which are serotype D and describing a new variety, C. neoformans var. grubii, for serotype A isolates.

Original languageEnglish (US)
Pages (from-to)838-840
Number of pages3
JournalJournal of clinical microbiology
Issue number3
StatePublished - Mar 1 1999
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology (medical)

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