Cryptococcus neoformans infection can elicit protective antibodies in mice

J. Mukherjee; M. D. Scharff; A. Casadevall

doi:10.1139/m94-141

Cryptococcus neoformans infection can elicit protective antibodies in mice

J. Mukherjee, M. D. Scharff, A. Casadevall

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.

Original language	English (US)
Pages (from-to)	888-892
Number of pages	5
Journal	Canadian Journal of Microbiology
Volume	40
Issue number	10
DOIs	https://doi.org/10.1139/m94-141
State	Published - 1994
Externally published	Yes

Keywords

Antibody immunity
Cryptococcus neoformans
Monoclonal antibody

ASJC Scopus subject areas

Microbiology
Immunology
Applied Microbiology and Biotechnology
Molecular Biology
Genetics

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10.1139/m94-141

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title = "Cryptococcus neoformans infection can elicit protective antibodies in mice",

abstract = "An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.",

keywords = "Antibody immunity, Cryptococcus neoformans, Monoclonal antibody",

author = "J. Mukherjee and Scharff, {M. D.} and A. Casadevall",

year = "1994",

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AU - Scharff, M. D.

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AB - An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.

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KW - Cryptococcus neoformans

KW - Monoclonal antibody

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Cryptococcus neoformans infection can elicit protective antibodies in mice

Abstract

Keywords

ASJC Scopus subject areas

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