Cryptococcus neoformans infection can elicit protective antibodies in mice

J. Mukherjee, M. D. Scharff, Arturo Casadevall

Research output: Contribution to journalArticle

Abstract

An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.

Original languageEnglish (US)
Pages (from-to)888-892
Number of pages5
JournalCanadian Journal of Microbiology
Volume40
Issue number10
StatePublished - 1994
Externally publishedYes

Fingerprint

Cryptococcus neoformans
Polysaccharides
Brain
Immunoglobulin G
Monoclonal Antibodies
Antibodies
Infection
Lung
Serum

Keywords

  • Antibody immunity
  • Cryptococcus neoformans
  • Monoclonal antibody

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biotechnology
  • Immunology
  • Microbiology

Cite this

Cryptococcus neoformans infection can elicit protective antibodies in mice. / Mukherjee, J.; Scharff, M. D.; Casadevall, Arturo.

In: Canadian Journal of Microbiology, Vol. 40, No. 10, 1994, p. 888-892.

Research output: Contribution to journalArticle

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