Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy

Anna Vecchiarelli, Eva Pericolini, Elena Gabrielli, Siu Kei Chow, Francesco Bistoni, Elio Cenci, Arturo Casadevall

Research output: Contribution to journalReview articlepeer-review

Abstract

Cryptococcus neoformans is an opportunistic fungal pathogen responsible for life-threatening infections in immunocompromised individuals and occasionally in those with no known immune impairment. The fungus is endowed with several virulence factors, including capsular polysaccharides that play a key role in virulence. The capsule is composed of 90-95% glucuronoxylomannan (GXM), 5-8% galactoxylomannan (GalXM) and <1% mannoproteins. Capsular polysaccharides are shed into tissue where they produce many deleterious effects. Since GalXM has a smaller molecular mass, the molar concentration of GalXM in polysaccharide that is shed could exceed that of GXM in C. neoformans exopolysaccharides. Moreover, GalXM exhibits a number of unusual biologic properties both in vitro and in vivo. Here, we summarize the principal immunomodulatory effects of GalXM described during the last 20 years, particularly the mechanisms leading to induction of apoptosis in T lymphocytes, B lymphocytes and macrophages. Since the capacity of GalXM to induce widespread immune suppression is believed to contribute to the virulence of C. neoformans, this property might be exploited therapeutically to dampen the aberrant activation of immune cells during autoimmune disorders.

Original languageEnglish (US)
Pages (from-to)997-1005
Number of pages9
JournalImmunotherapy
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • B cell
  • CD45
  • T cell
  • apoptosis
  • galactoxylomannan
  • macrophage
  • proliferation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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