Cryptococcal lymphadenitis and immune reconstitution inflammatory syndrome: Current considerations

Vijesh Kuttiatt, Prarthana Sreenivasa, Isha Garg, Anita Shet

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-related immune reconstitution inflammatory syndrome (IRIS) is increasingly being recognized in regions with a high burden of opportunistic infections. We describe an unusual manifestation of IRIS- unmasking cryptococcal lymphadenitis in a patient shortly after initiation of antiretroviral therapy. Epidemiology, clinical features and management of cryptococcal IRIS with reference to lymphadenitis presentation are briefly reviewed. Early and accurate diagnosis is essential for appropriate management. Standard antifungal therapy along with continuation of antiretroviral therapy is recommended. Cases with severe inflammation may benefit from anti-inflammatory drugs/corticosteroids. Unusual manifestations like lymphadenitis pose diagnostic difficulties in regions with a high prevalence of tubercular lymphadenitis.

Original languageEnglish (US)
Pages (from-to)664-668
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume43
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Cryptococcal lymphadenitis
  • Human immunodeficiency virus (HIV)
  • Immune reconstitution inflammatory syndrome (IRIS)

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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