Cryotherapy enhances intravitreal dispersion of viable retinal pigment epithelial cells

Peter A. Campochiaro, Ian H. Kaden, Jesus Vidaurri Leal, Bert M. Glaser

Research output: Contribution to journalArticlepeer-review


Proliferative vitreoretinopathy (PVR) is the most common cause of failure in retinal reattachment surgery. Giant retinal tears are associated with a particularly high incidence of PVR. It involves the formation of cellular membranes that contract and cause traction retinal detachments. Retinal pigment epithelial (RPE) cells are a major component of these cellular membranes. Displacement of viable RPE cells from their normal position into the vitreous cavity is necessary for membrane formation to occur. This study demonstrates that cryotherapy, but not diathermy, enhances intravitreal dispersion of viable RPE cells in bovine eyes in vitro. This suggests that in some circumstances, excessive cryotherapy may play an exacerbating role in the initiation of PVR.

Original languageEnglish (US)
Pages (from-to)434-436
Number of pages3
JournalArchives of ophthalmology
Issue number3
StatePublished - Mar 1985

ASJC Scopus subject areas

  • Ophthalmology


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