TY - JOUR
T1 - Cryotherapy causes extensive breakdown of the blood-retinal barrier
T2 - A comparison with argon laser photocoagulation
AU - Jaccoma, Edward H.
AU - Conway, Brian P.
AU - Campochiaro, Peter A.
PY - 1985/11
Y1 - 1985/11
N2 - Using computerized vitreous fluorophotometry (VFP) in pigmented rabbits, we examined two modalities frequently used in retinal reattachment surgery, cryotherapy and argon laser photocoagulation, for their effect on the blood-retinal barrier. The VFP readings were taken 2 mm posterior to the lens one hour after intravenous injection of 14 mg/kg of fluorescein sodium. After baseline fluorophotometry readings, rabbits were treated with confluent cryotherapy over the inferior 180° in one eye and with confluent laser over an equivalent area of retina in the other eye. The VFP readings were taken 2, 4, 6, and 15 days after treatment. By day 6, the VFP reading had risen from a pretreatment value of 6.4 ± 0.4 ng/mL to 41.8 ± 7.9 ng/mL in the cryotherapytreated eyes as opposed to 15.5 ±3.1 ng/mL in the laser-treated eyes. By day 15, the readings were almost back to baseline, and there was no significant difference between the two treatment groups. These data suggest that there is a significant breakdown of the blood-retinal barrier with both modalities, but that it is considerably more severe with cryotherapy.
AB - Using computerized vitreous fluorophotometry (VFP) in pigmented rabbits, we examined two modalities frequently used in retinal reattachment surgery, cryotherapy and argon laser photocoagulation, for their effect on the blood-retinal barrier. The VFP readings were taken 2 mm posterior to the lens one hour after intravenous injection of 14 mg/kg of fluorescein sodium. After baseline fluorophotometry readings, rabbits were treated with confluent cryotherapy over the inferior 180° in one eye and with confluent laser over an equivalent area of retina in the other eye. The VFP readings were taken 2, 4, 6, and 15 days after treatment. By day 6, the VFP reading had risen from a pretreatment value of 6.4 ± 0.4 ng/mL to 41.8 ± 7.9 ng/mL in the cryotherapytreated eyes as opposed to 15.5 ±3.1 ng/mL in the laser-treated eyes. By day 15, the readings were almost back to baseline, and there was no significant difference between the two treatment groups. These data suggest that there is a significant breakdown of the blood-retinal barrier with both modalities, but that it is considerably more severe with cryotherapy.
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U2 - 10.1001/archopht.1985.01050110124039
DO - 10.1001/archopht.1985.01050110124039
M3 - Article
C2 - 4062641
AN - SCOPUS:0022359750
VL - 103
SP - 1728
EP - 1730
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 11
ER -