Cryopreservation of all prezygotes in patients at risk of severe hyperstimulation does not eliminate the syndrome, but the chances of pregnancy are excellent with subsequent frozen-thaw transfers

J. T. Queenan, L. L. Veeck, J. P. Toner, S. Oehninger, S. J. Muasher

Research output: Contribution to journalArticle

Abstract

In-vitro fertilization patients (n = 15) at risk of ovarian hyperstimulation syndrome (OHSS) (oestradiol ≤ 4500 pg/ml on the day of human chorionic gonadotrophin administration and 25 or more follicles of intermediate or large size) underwent aspiration of all follicles and cryopreservation of all fertilized oocytes at the pronuclear stage. Patients were monitored for up to 2 weeks post-retrieval. Subsequent transfer of cryopreserved-thawed embryos was performed in programmed cycles using exogenous oestrogen and progesterone for endometrial preparation. Two patients (13%) developed OHSS necessitating hospitalization and vaginal aspiration of ascitic fluid. Two other patients (13%) developed moderate OHSS requiring ascitic fluid vaginal aspiration in the office setting, with dramatic improvement of the condition. Subsequent transfer of cryopreserved-thawed embryos yielded a clinical pregnancy rate of 58% per transfer and ongoing or delivery rates of 42 and 67% per transfer and per patient respectively. By eliminating pregnancy potential with cryopreservation of all prezygotes and examining the pregnancy potential with subsequent cryopreserved-thawed transfers, it is concluded that OHSS is reduced, but not eliminated for patients at risk. Subsequent transfer of cryopreserved-thawed prezygotes in a programmed cycle with exogenous steroids yields an excellent pregnancy rate.

Original languageEnglish (US)
Pages (from-to)1573-1576
Number of pages4
JournalHuman Reproduction
Volume12
Issue number7
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Cryopreservation
Ovarian Hyperstimulation Syndrome
Pregnancy
Ascitic Fluid
Pregnancy Rate
Embryonic Structures
Patient Transfer
Chorionic Gonadotropin
Fertilization in Vitro
Oocytes
Progesterone
Estradiol
Estrogens
Hospitalization
Steroids

Keywords

  • Cryopreservation
  • Embryos
  • IVF
  • Ovarian hyperstimulation syndrome (OHSS)

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Cryopreservation of all prezygotes in patients at risk of severe hyperstimulation does not eliminate the syndrome, but the chances of pregnancy are excellent with subsequent frozen-thaw transfers. / Queenan, J. T.; Veeck, L. L.; Toner, J. P.; Oehninger, S.; Muasher, S. J.

In: Human Reproduction, Vol. 12, No. 7, 1997, p. 1573-1576.

Research output: Contribution to journalArticle

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