TY - JOUR
T1 - Cryoprecipitate as a Reliable Source of Fibrinogen Replacement
AU - Ness, Paul M.
AU - Perkins, Herbert A.
PY - 1979/4/20
Y1 - 1979/4/20
N2 - The recent withdrawal of commercial fibrinogen from the market makes alternate sources most important. Although it has been previously reported that single-donor cryoprecipitate contains appreciable amounts of fibrinogen, most clinicians need to be reminded of the reliability of cryoprecipitate for replacement of both fibrinogen and factor VIII. We assayed fibrinogen from 88 bags of cryoprecipitate prepared by five different blood banks in California and Oregon; we found that the average bag of cryoprecipitate contains at least 250 mg of fibrinogen depending on the volume of plasma processed. Cryoprecipitate was found to be a poor source of factors II, V, IX, X, XI, and XII. (JAMA 241:1690-1691, 1979).
AB - The recent withdrawal of commercial fibrinogen from the market makes alternate sources most important. Although it has been previously reported that single-donor cryoprecipitate contains appreciable amounts of fibrinogen, most clinicians need to be reminded of the reliability of cryoprecipitate for replacement of both fibrinogen and factor VIII. We assayed fibrinogen from 88 bags of cryoprecipitate prepared by five different blood banks in California and Oregon; we found that the average bag of cryoprecipitate contains at least 250 mg of fibrinogen depending on the volume of plasma processed. Cryoprecipitate was found to be a poor source of factors II, V, IX, X, XI, and XII. (JAMA 241:1690-1691, 1979).
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U2 - 10.1001/jama.1979.03290420016016
DO - 10.1001/jama.1979.03290420016016
M3 - Article
C2 - 430729
AN - SCOPUS:0018796443
SN - 0098-7484
VL - 241
SP - 1690
EP - 1691
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 16
ER -